Visual working memory impairment in premanifest gene-carriers and early Huntington's disease

Eve M Dumas, Miranda J Say, Rebecca Jones, Izelle Labuschagne, Alison Margaret O'Regan, Ellen P Hart, Simon J A van den Bogaard, Sarah Queller, Damian Justo, Allison Coleman, Rachelle C Dar Santos, Alexandra Durr, Blair R Leavitt, Sarah J Tabrizi, Raymond A C Roos, Julie C Stout

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14 Citations (Scopus)

Abstract

Working memory deficits have been found in Huntington?s disease (HD) and in a small group of premanifest (PreHD) gene-carriers. However, the nature and extent of these deficits are unknown. In a large cross-sectional study, we aimed to determine the degree of visuospatial working memory dysfunction across multiple stages of HD. Specifically, visuospatial working memory capacity and response times across various degrees of difficulty were examined, as well as the relationship between visuospatial working memory and motor dysfunction.
Original languageEnglish
Pages (from-to)97 - 106
Number of pages10
JournalJournal of Huntington's Disease
Volume1
Issue number1
DOIs
Publication statusPublished - 2012

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