Visual cortical area MT is required for development of the dorsal stream and associated visuomotor behaviors

William C. Kwan, Chia Kang Chang, Hsin-Hao Yu, Inaki C. Mundinano, Dylan M. Fox, Jihane Homman-Ludiye, James A. Bourne

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2 Citations (Scopus)


The middle temporal (MT) area of the extrastriate visual cortex has long been studied in adulthood for its distinctive physiological properties and function as a part of the dorsal stream, yet interestingly it possesses a similar maturation profile as the primary visual cortex (V1). Here, we examined whether an early-life lesion in MT of marmoset monkeys (six female, two male) altered the dorsal stream development and the behavioral precision of reaching-to-grasp sequences. We observed permanent changes in the anatomy of cortices associated with both reaching (parietal and medial intraparietal areas) and grasping (anterior intraparietal area), as well as in reaching-and-grasping behaviors. In addition, we observed a significant impact on the anatomy of V1 and the direction sensitivity of V1 neurons in the lesion projection zone. These findings indicate that area MT is a crucial node in the development of primate vision, affecting both V1 and areas in the dorsal visual pathway known to mediate visually guided manual behaviors.

Original languageEnglish
Pages (from-to)8197-8209
Number of pages13
JournalThe Journal of Neuroscience
Issue number39
Publication statusPublished - 29 Sep 2021


  • Lesion
  • Marmoset
  • Middle temporal area
  • MRI
  • Visual cortex

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