Visible-light-mediated cleavage of polymer chains under physiological conditions via quinone photoreduction and trimethyl lock

Vinh X. Truong, Fanyi Li, Francesca Ercole, John S. Forsythe

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications. Both reactions can be carried out in water and at ambient temperature, enabling preparation of bioorthogonal hydrogels for encapsulation and controlled release of various cells.

Original languageEnglish
Pages (from-to)12076-12079
Number of pages4
JournalChemical Communications
Issue number89
Publication statusPublished - 2017

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