Visceral adiposity and insular networks

associations with food craving

Oren Contreras-Rodríguez, Marta Cano, Raquel Vilar-López, Jacqueline Schmidt Rio-Valle, Juan Verdejo-Román, Juan F. Navas, Cristina Martín-Pérez, Fernando Fernández-Aranda, José Manuel Menchón, Carles Soriano-Mas, Antonio Verdejo-García

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Background/objectives: Accumulation of visceral adiposity can disrupt the brain’s sensitivity to interoceptive feedback, which is coded in the insula. This study aimed to test the link between visceral fat and the functional connectivity of two insulae regions relevant for eating behavior: the middle-dorsal insula (mIns), which codes homeostatic changes, and the rostral insula (rIns), which codes stable representations of food properties. We also assessed the impact of visceral adiposity-associated insulae networks on food craving. Subjects/methods: Seventy-five adults ranging in weight status (normal and excess weight) underwent resting-state functional magnetic resonance imaging (fMRI) and subjective food craving measures. We examined the association between visceral fat and seed-based functional connectivity of the mIns and the rIns, controlling for BMI, age, and sex, using multiple regressions in SPM8. We also tested if visceral fat mediated the association between insulae connectivity and food craving. Results: Higher visceral adiposity was associated with decreased connectivity between the mIns and a cluster involving the hypothalamus and the bed nucleus of the stria terminalis. Decreased connectivity in this network was associated with greater food craving, a relation mediated by visceral adiposity. Visceral adiposity was also associated with increased connectivity between the mIns and the middle frontal gyri and the right intraparietal cortex, and between the rIns and the right amygdala. Conclusions: Accumulation of visceral adiposity is linked to disrupted functional connectivity within the mIns and rIns networks. Furthermore, the link between the mIns network and food craving is mediated by visceral fat. Findings suggest that visceral fat disrupts insula coding of bodily homeostatic signals, which may boost externally driven food cravings.

Original languageEnglish
Pages (from-to)503-511
Number of pages9
JournalInternational Journal of Obesity
Volume43
Issue number3
DOIs
Publication statusPublished - 2019

Cite this

Contreras-Rodríguez, O., Cano, M., Vilar-López, R., Rio-Valle, J. S., Verdejo-Román, J., Navas, J. F., ... Verdejo-García, A. (2019). Visceral adiposity and insular networks: associations with food craving. International Journal of Obesity, 43(3), 503-511. https://doi.org/10.1038/s41366-018-0173-3
Contreras-Rodríguez, Oren ; Cano, Marta ; Vilar-López, Raquel ; Rio-Valle, Jacqueline Schmidt ; Verdejo-Román, Juan ; Navas, Juan F. ; Martín-Pérez, Cristina ; Fernández-Aranda, Fernando ; Menchón, José Manuel ; Soriano-Mas, Carles ; Verdejo-García, Antonio. / Visceral adiposity and insular networks : associations with food craving. In: International Journal of Obesity. 2019 ; Vol. 43, No. 3. pp. 503-511.
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title = "Visceral adiposity and insular networks: associations with food craving",
abstract = "Background/objectives: Accumulation of visceral adiposity can disrupt the brain’s sensitivity to interoceptive feedback, which is coded in the insula. This study aimed to test the link between visceral fat and the functional connectivity of two insulae regions relevant for eating behavior: the middle-dorsal insula (mIns), which codes homeostatic changes, and the rostral insula (rIns), which codes stable representations of food properties. We also assessed the impact of visceral adiposity-associated insulae networks on food craving. Subjects/methods: Seventy-five adults ranging in weight status (normal and excess weight) underwent resting-state functional magnetic resonance imaging (fMRI) and subjective food craving measures. We examined the association between visceral fat and seed-based functional connectivity of the mIns and the rIns, controlling for BMI, age, and sex, using multiple regressions in SPM8. We also tested if visceral fat mediated the association between insulae connectivity and food craving. Results: Higher visceral adiposity was associated with decreased connectivity between the mIns and a cluster involving the hypothalamus and the bed nucleus of the stria terminalis. Decreased connectivity in this network was associated with greater food craving, a relation mediated by visceral adiposity. Visceral adiposity was also associated with increased connectivity between the mIns and the middle frontal gyri and the right intraparietal cortex, and between the rIns and the right amygdala. Conclusions: Accumulation of visceral adiposity is linked to disrupted functional connectivity within the mIns and rIns networks. Furthermore, the link between the mIns network and food craving is mediated by visceral fat. Findings suggest that visceral fat disrupts insula coding of bodily homeostatic signals, which may boost externally driven food cravings.",
author = "Oren Contreras-Rodr{\'i}guez and Marta Cano and Raquel Vilar-L{\'o}pez and Rio-Valle, {Jacqueline Schmidt} and Juan Verdejo-Rom{\'a}n and Navas, {Juan F.} and Cristina Mart{\'i}n-P{\'e}rez and Fernando Fern{\'a}ndez-Aranda and Mench{\'o}n, {Jos{\'e} Manuel} and Carles Soriano-Mas and Antonio Verdejo-Garc{\'i}a",
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Contreras-Rodríguez, O, Cano, M, Vilar-López, R, Rio-Valle, JS, Verdejo-Román, J, Navas, JF, Martín-Pérez, C, Fernández-Aranda, F, Menchón, JM, Soriano-Mas, C & Verdejo-García, A 2019, 'Visceral adiposity and insular networks: associations with food craving', International Journal of Obesity, vol. 43, no. 3, pp. 503-511. https://doi.org/10.1038/s41366-018-0173-3

Visceral adiposity and insular networks : associations with food craving. / Contreras-Rodríguez, Oren; Cano, Marta; Vilar-López, Raquel; Rio-Valle, Jacqueline Schmidt; Verdejo-Román, Juan; Navas, Juan F.; Martín-Pérez, Cristina; Fernández-Aranda, Fernando; Menchón, José Manuel; Soriano-Mas, Carles; Verdejo-García, Antonio.

In: International Journal of Obesity, Vol. 43, No. 3, 2019, p. 503-511.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Visceral adiposity and insular networks

T2 - associations with food craving

AU - Contreras-Rodríguez, Oren

AU - Cano, Marta

AU - Vilar-López, Raquel

AU - Rio-Valle, Jacqueline Schmidt

AU - Verdejo-Román, Juan

AU - Navas, Juan F.

AU - Martín-Pérez, Cristina

AU - Fernández-Aranda, Fernando

AU - Menchón, José Manuel

AU - Soriano-Mas, Carles

AU - Verdejo-García, Antonio

PY - 2019

Y1 - 2019

N2 - Background/objectives: Accumulation of visceral adiposity can disrupt the brain’s sensitivity to interoceptive feedback, which is coded in the insula. This study aimed to test the link between visceral fat and the functional connectivity of two insulae regions relevant for eating behavior: the middle-dorsal insula (mIns), which codes homeostatic changes, and the rostral insula (rIns), which codes stable representations of food properties. We also assessed the impact of visceral adiposity-associated insulae networks on food craving. Subjects/methods: Seventy-five adults ranging in weight status (normal and excess weight) underwent resting-state functional magnetic resonance imaging (fMRI) and subjective food craving measures. We examined the association between visceral fat and seed-based functional connectivity of the mIns and the rIns, controlling for BMI, age, and sex, using multiple regressions in SPM8. We also tested if visceral fat mediated the association between insulae connectivity and food craving. Results: Higher visceral adiposity was associated with decreased connectivity between the mIns and a cluster involving the hypothalamus and the bed nucleus of the stria terminalis. Decreased connectivity in this network was associated with greater food craving, a relation mediated by visceral adiposity. Visceral adiposity was also associated with increased connectivity between the mIns and the middle frontal gyri and the right intraparietal cortex, and between the rIns and the right amygdala. Conclusions: Accumulation of visceral adiposity is linked to disrupted functional connectivity within the mIns and rIns networks. Furthermore, the link between the mIns network and food craving is mediated by visceral fat. Findings suggest that visceral fat disrupts insula coding of bodily homeostatic signals, which may boost externally driven food cravings.

AB - Background/objectives: Accumulation of visceral adiposity can disrupt the brain’s sensitivity to interoceptive feedback, which is coded in the insula. This study aimed to test the link between visceral fat and the functional connectivity of two insulae regions relevant for eating behavior: the middle-dorsal insula (mIns), which codes homeostatic changes, and the rostral insula (rIns), which codes stable representations of food properties. We also assessed the impact of visceral adiposity-associated insulae networks on food craving. Subjects/methods: Seventy-five adults ranging in weight status (normal and excess weight) underwent resting-state functional magnetic resonance imaging (fMRI) and subjective food craving measures. We examined the association between visceral fat and seed-based functional connectivity of the mIns and the rIns, controlling for BMI, age, and sex, using multiple regressions in SPM8. We also tested if visceral fat mediated the association between insulae connectivity and food craving. Results: Higher visceral adiposity was associated with decreased connectivity between the mIns and a cluster involving the hypothalamus and the bed nucleus of the stria terminalis. Decreased connectivity in this network was associated with greater food craving, a relation mediated by visceral adiposity. Visceral adiposity was also associated with increased connectivity between the mIns and the middle frontal gyri and the right intraparietal cortex, and between the rIns and the right amygdala. Conclusions: Accumulation of visceral adiposity is linked to disrupted functional connectivity within the mIns and rIns networks. Furthermore, the link between the mIns network and food craving is mediated by visceral fat. Findings suggest that visceral fat disrupts insula coding of bodily homeostatic signals, which may boost externally driven food cravings.

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Contreras-Rodríguez O, Cano M, Vilar-López R, Rio-Valle JS, Verdejo-Román J, Navas JF et al. Visceral adiposity and insular networks: associations with food craving. International Journal of Obesity. 2019;43(3):503-511. https://doi.org/10.1038/s41366-018-0173-3