Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of aging, respectively

Thomas A Angelovich, Anna C. Hearps, Anna Maisa, Genevieve E. Martin, Gregor F. Lichtfuss, Wan-Jung Cheng, Clovis S. Palmer, Alan L Landay, Suzanne M. Crowe, Anthony Jaworowski

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Background: Chronic inflammation and immune activation occur in both HIV infection and normal aging and are associated with inflammatory disease. However, the degree to which HIV influences age-related innate immune changes, and the biomarkers which best reflect them, remains unclear. Methods and Results: We measured established innate immune aging biomarkers in 309 individuals including 88 virologically suppressed (VS) and 52 viremic (viral load ≤ and >50 copies per milliliter, respectively) HIV-positive individuals. Levels of soluble (ie, CXCL10, soluble CD163, neopterin) and cellular (ie, proportions of inflammatory CD16 + monocytes) biomarkers of monocyte activation were increased in HIV-positive individuals and were only partially ameliorated by viral suppression. Viremic and VS HIV-positive individuals show levels of age-related monocyte activation biomarkers that are similar to uninfected controls aged 12 and 4 years older, respectively. Viremic HIV infection was associated with an accelerated rate of change of some monocyte activation markers (eg, neopterin) with age, whereas in VS individuals, subsequent age-related changes occurred at a similar rate as in controls, albeit at a higher absolute level. We further identified CXCL10 as a robust soluble biomarker of monocyte activation, highlighting the potential utility of this chemokine as a prognostic marker. Implications: These findings may partially explain the increased prevalence of inflammatory age-related diseases in HIV-positive individuals and potentially indicate the pathological mechanisms underlying these diseases, which persist despite viral suppression.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalJAIDS
Volume69
Issue number1
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • aging
  • HIV
  • innate immune activation
  • monocyte

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