Viral determinants and vector competence of Zika Virus transmission

Hong Wai Tham, Vinod Balasubramaniam, Man K. Ooi, Miaw Fang Chew

    Research output: Contribution to journalReview ArticleOtherpeer-review

    13 Citations (Scopus)


    Zika virus (ZIKV) has emerged as a new global health threat. Since its first discovery in Zika forest in Uganda, this virus has been isolated from several mosquito species, including Aedes aegypti and Aedes albopictus. The geographical distribution of these mosquito species across tropical and subtropical regions has led to several outbreaks, including the recent pandemic in Brazil, followed by the Pacific islands and other areas of North and South America. This has gained attention of the scientific community to elucidate the epidemiology and transmission of ZIKV. Despite its strong attention on clinical aspects for healthcare professionals, the relationships between ZIKV and its principal vectors, A. aegypti and A. albopictus, have not gained substantial interest in the scientific research community. As such, this review aims to summarize the current knowledge on ZIKV tropism and some important mechanisms which may be employed by the virus for effective strategies on viral survival in mosquitoes. In addition, this review identifies the areas of research that should be placed attention to, for which to be exploited for novel mosquito control strategies.

    Original languageEnglish
    Article number1040
    Number of pages11
    JournalFrontiers in Microbiology
    Issue numberMAY
    Publication statusPublished - 23 May 2018


    • Arboviruses
    • Mosquitoes
    • Vector competence
    • Viral determinants
    • Zika virus

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