Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

Christopher Desmond; Silvana Gaudieri; Ian R James; Katja Pfafferott; Abha Chopra; George Lau; Jennifer Audsley; Caroline Day; Sarah Chivers; Adam Gordon; Peter A Revill; Scott Bowden; Anna Ayres; Paul V Desmond; Alexander J Thompson; Stuart K Roberts; Stephen A Locarnini; Simon A Mallal; Sharon Ruth Lewin

doi:10.1128/JVI.05308-11

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

Christopher Desmond, Silvana Gaudieri, Ian R James, Katja Pfafferott, Abha Chopra, George Lau, Jennifer Audsley, Caroline Day, Sarah Chivers, Adam Gordon, Peter A Revill, Scott Bowden, Anna Ayres, Paul V Desmond, Alexander J Thompson, Stuart K Roberts, Stephen A Locarnini, Simon A Mallal, Sharon Ruth Lewin

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

43 Citations (Scopus)

Abstract

We aimed to identify novel HBV T-cell epitopes by examining the relationship between HBV sequence variation and the human leukocyte antigen (HLA) type in a large prospective clinic-based cohort of Asian patients with chronic HBV infection recruited in Australia and China (n = 119).

Original language	English
Pages (from-to)	1181 - 1192
Number of pages	12
Journal	Journal of Virology
Volume	86
Issue number	2
DOIs	https://doi.org/10.1128/JVI.05308-11
Publication status	Published - 2012

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Desmond, C., Gaudieri, S., James, I. R., Pfafferott, K., Chopra, A., Lau, G., Audsley, J., Day, C., Chivers, S., Gordon, A., Revill, P. A., Bowden, S., Ayres, A., Desmond, P. V., Thompson, A. J., Roberts, S. K., Locarnini, S. A., Mallal, S. A., & Lewin, S. R. (2012). Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease. Journal of Virology, 86(2), 1181 - 1192. https://doi.org/10.1128/JVI.05308-11

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title = "Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease",

abstract = "We aimed to identify novel HBV T-cell epitopes by examining the relationship between HBV sequence variation and the human leukocyte antigen (HLA) type in a large prospective clinic-based cohort of Asian patients with chronic HBV infection recruited in Australia and China (n = 119).",

author = "Christopher Desmond and Silvana Gaudieri and James, {Ian R} and Katja Pfafferott and Abha Chopra and George Lau and Jennifer Audsley and Caroline Day and Sarah Chivers and Adam Gordon and Revill, {Peter A} and Scott Bowden and Anna Ayres and Desmond, {Paul V} and Thompson, {Alexander J} and Roberts, {Stuart K} and Locarnini, {Stephen A} and Mallal, {Simon A} and Lewin, {Sharon Ruth}",

year = "2012",

doi = "10.1128/JVI.05308-11",

language = "English",

volume = "86",

pages = "1181 -- 1192",

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publisher = "American Society for Microbiology",

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Desmond, C, Gaudieri, S, James, IR, Pfafferott, K, Chopra, A, Lau, G, Audsley, J, Day, C, Chivers, S, Gordon, A, Revill, PA, Bowden, S, Ayres, A, Desmond, PV, Thompson, AJ, Roberts, SK, Locarnini, SA, Mallal, SA & Lewin, SR 2012, 'Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease', Journal of Virology, vol. 86, no. 2, pp. 1181 - 1192. https://doi.org/10.1128/JVI.05308-11

TY - JOUR

T1 - Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

AU - Desmond, Christopher

AU - Gaudieri, Silvana

AU - James, Ian R

AU - Pfafferott, Katja

AU - Chopra, Abha

AU - Lau, George

AU - Audsley, Jennifer

AU - Day, Caroline

AU - Chivers, Sarah

AU - Gordon, Adam

AU - Revill, Peter A

AU - Bowden, Scott

AU - Ayres, Anna

AU - Desmond, Paul V

AU - Thompson, Alexander J

AU - Roberts, Stuart K

AU - Locarnini, Stephen A

AU - Mallal, Simon A

AU - Lewin, Sharon Ruth

PY - 2012

Y1 - 2012

N2 - We aimed to identify novel HBV T-cell epitopes by examining the relationship between HBV sequence variation and the human leukocyte antigen (HLA) type in a large prospective clinic-based cohort of Asian patients with chronic HBV infection recruited in Australia and China (n = 119).

AB - We aimed to identify novel HBV T-cell epitopes by examining the relationship between HBV sequence variation and the human leukocyte antigen (HLA) type in a large prospective clinic-based cohort of Asian patients with chronic HBV infection recruited in Australia and China (n = 119).

UR - http://jvi.asm.org/content/86/2/1181.full.pdf

U2 - 10.1128/JVI.05308-11

DO - 10.1128/JVI.05308-11

M3 - Article

SN - 0022-538X

VL - 86

SP - 1181

EP - 1192

JO - Journal of Virology

JF - Journal of Virology

IS - 2

ER -

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

Abstract

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