Very preterm infants failing CPAP show signs of fatigue immediately after birth

Melissa Li-Lian Siew, Jeroen J van Vonderen, Stuart Brian Hooper, Arjan B Te Pas

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OBJECTIVE: To investigate the differences in breathing pattern and effort in infants at birth who failed or succeeded on continuous positive airway pressure (CPAP) during the first 48 hours after birth. METHODS: Respiratory function recordings of 32 preterm infants were reviewed of which 15 infants with a gestational age of 28.6 (0.7) weeks failed CPAP and 17 infants with a GA of 30.1 (0.4) weeks did not fail CPAP. Frequency, duration and tidal volumes (VT) of expiratory holds (EHs), peak inspiratory flows, CPAP-level and FiO2-levels were analysed. RESULTS: EH incidence increased 9 ml/kg) with higher peak inspiratory flows than CPAP-fail infants (71.8 +/- 15.8 vs. 15.5 +/- 5.2 ml/kg.s, p
Original languageEnglish
Article numbere0129592
Number of pages15
JournalPLoS ONE
Issue number6
Publication statusPublished - 2015

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