Vertically configured nanostructure-mediated electroporation: A promising route for intracellular regulations and interrogations

Ali Reza Shokouhi, Stella Aslanoglou, David Nisbet, Nicolas H. Voelcker, Roey Elnathan

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)


The ability to generate programmable vertically aligned 1D nanoscale substrate topography has spurred advances in five fields of cellular nanotechnology: nanoelectrode-based electrophysiology, intracellular delivery, biosensing, mechanotransduction, and-the focus of this review-understanding the key parameters that govern nanostructure-mediated electroporation for diverse cellular manipulations. The integration of 1D nanostructures into conventional cell manipulation and interrogation systems, based on electroporation, has engendered significant interest over the past decade. We evaluate the latest and most influential studies on engineered nanostructure-mediated electroporation platforms, focusing on the use of tuneable, vertically configured nanostructures-in particular, vertically aligned nanowire, nanostraw, and nanotube arrays-to orchestrate cellular processes such as intracellular delivery, biomolecular extraction, and action potential probing, via both experimental and theoretical studies. This journal is

Original languageEnglish
Pages (from-to)2810-2831
Number of pages22
JournalMaterials Horizons
Issue number11
Publication statusPublished - Nov 2020

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