Vertebrate myotome development

Georgina E Hollway, Peter David Currie

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)


The embryonic myotome generates both the axial musculature and the appendicular muscle of the fins and limbs. Early in embryo development the mesoderm is segmented into somites, and within these the primary myotome forms by a complex series of cellular movements and migrations. A new model of primary myotome formation in amniotes has emerged recently. The myotome also includes the muscle progenitor cells that are known to contribute to the secondary formation of the myotome. The adult myotome contains satellite cells that play an important role in adult muscle regeneration. Recent studies have shed light on how the growth and patterning of the myotome occurs.
Original languageEnglish
Pages (from-to)172 - 179
Number of pages8
JournalBirth Defects Research Part C: Embryo Today Reviews
Issue number3
Publication statusPublished - 2005
Externally publishedYes

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