Verification of a relaxin-3 knockout/LacZ reporter mouse as a model of relaxin-3 deficiency

Craig M. Smith, Pei Juan Shen, Sherie Ma, Steve W. Sutton, Andrew L. Gundlach

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

16 Citations (Scopus)

Abstract

Research on the neuropeptide relaxin-3 has predominately been conducted in rats. Anatomical studies have yielded important information on the distribution of relaxin-3 and its cognate receptor (RXFP3) within the brain, while functional studies have implicated relaxin-3 as a modulator of feeding and stress responses. Therefore, the relaxin-3/RXFP3 system represents a potential target for novel drugs to treat human disorders such as obesity, anxiety, and depression, but more research into this interesting neuropeptide in different experimental species is still required. Before conducting detailed neurochemical and behavioral examinations of a recently generated relaxin-3 knockout mouse strain, the present study determined whether this mouse was a viable model of relaxin-3 deficiency.

Original languageEnglish
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherWiley-Blackwell
Pages259-260
Number of pages2
ISBN (Print)9781573317214
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Immunohistochemistry
  • Knockout mouse
  • LacZ reporter
  • Phenotype
  • Relaxin-3
  • RXFP3/GPCR135

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