Ventricular metastasis resulting in disseminated intravascular coagulation

Thomas John, Ian D. Davis

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4 Citations (Scopus)


Background: Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with DIC. Case presentation: A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusion: Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices.

Original languageEnglish
Article number29
JournalWorld Journal of Surgical Oncology
Publication statusPublished - 24 May 2005

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