Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation

Sue R Downie, Cheryl M Salome, Sylvia Verbanck, Bruce Thompson, Norbert Berend, Gregory G King

Research output: Contribution to journalArticleResearchpeer-review

165 Citations (Scopus)

Abstract

BACKGROUND: Airway hyperresponsiveness is the ability of airways to narrow excessively in response to inhaled stimuli and is a key feature of asthma. Airway inflammation and ventilation heterogeneity have been separately shown to be associated with airway hyperresponsiveness. A study was undertaken to establish whether ventilation heterogeneity is associated with airway hyperresponsiveness independently of airway inflammation in subjects with asthma and to determine the effect of inhaled corticosteroids on this relationship. METHODS: Airway inflammation was measured in 40 subjects with asthma by exhaled nitric oxide, ventilation heterogeneity by multiple breath nitrogen washout and airway hyperresponsiveness by methacholine challenge. In 18 of these subjects with uncontrolled symptoms, measurements were repeated after 3 months of treatment with inhaled beclomethasone dipropionate. RESULTS: At baseline, airway hyperresponsiveness was independently predicted by airway inflammation (partial r2 = 0.20, p
Original languageEnglish
Pages (from-to)684 - 689
Number of pages6
JournalThorax
Volume62
Issue number8
Publication statusPublished - 2007

Cite this

Downie, S. R., Salome, C. M., Verbanck, S., Thompson, B., Berend, N., & King, G. G. (2007). Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax, 62(8), 684 - 689.