Venovenous extracorporeal membrane oxygenation for acute respiratory failure

A clinical review from an international group of experts

Eddy Fan, Luciano Gattinoni, Alain Combes, Matthieu Schmidt, Giles Peek, Dan Brodie, Thomas Muller, Andrea Morelli, V. Marco Ranieri, Antonio Pesenti, Laurent Brochard, Carol Hodgson, Cecile Van Kiersbilck, Antoine Roch, Michael Quintel, Laurent Papazian

Research output: Contribution to journalReview ArticleResearchpeer-review

70 Citations (Scopus)

Abstract

Despite expensive life-sustaining interventions delivered in the ICU, mortality and morbidity in patients with acute respiratory failure (ARF) remain unacceptably high. Extracorporeal membrane oxygenation (ECMO) has emerged as a promising intervention that may provide more efficacious supportive care to these patients. Improvements in technology have made ECMO safer and easier to use, allowing for the potential of more widespread application in patients with ARF. A greater appreciation of the complications associated with the placement of an artificial airway and mechanical ventilation has led clinicians and researchers to seek viable alternatives to providing supportive care in these patients. Thus, this review will summarize the current knowledge regarding the use of venovenous (VV)-ECMO for ARF and describe some of the recent controversies in the field, such as mechanical ventilation, anticoagulation and transfusion therapy, and ethical concerns in patients supported with VV-ECMO.

Original languageEnglish
Pages (from-to)712-724
Number of pages13
JournalIntensive Care Medicine
Volume42
Issue number5
DOIs
Publication statusPublished - 1 May 2016

Keywords

  • Critical care
  • Extracorporeal membrane oxygenation
  • Intensive care units
  • Respiratory distress syndrome
  • Respiratory failure
  • Review
  • Adult
  • Ventilation
  • artificial

Cite this

Fan, Eddy ; Gattinoni, Luciano ; Combes, Alain ; Schmidt, Matthieu ; Peek, Giles ; Brodie, Dan ; Muller, Thomas ; Morelli, Andrea ; Ranieri, V. Marco ; Pesenti, Antonio ; Brochard, Laurent ; Hodgson, Carol ; Van Kiersbilck, Cecile ; Roch, Antoine ; Quintel, Michael ; Papazian, Laurent. / Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts. In: Intensive Care Medicine. 2016 ; Vol. 42, No. 5. pp. 712-724.
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abstract = "Despite expensive life-sustaining interventions delivered in the ICU, mortality and morbidity in patients with acute respiratory failure (ARF) remain unacceptably high. Extracorporeal membrane oxygenation (ECMO) has emerged as a promising intervention that may provide more efficacious supportive care to these patients. Improvements in technology have made ECMO safer and easier to use, allowing for the potential of more widespread application in patients with ARF. A greater appreciation of the complications associated with the placement of an artificial airway and mechanical ventilation has led clinicians and researchers to seek viable alternatives to providing supportive care in these patients. Thus, this review will summarize the current knowledge regarding the use of venovenous (VV)-ECMO for ARF and describe some of the recent controversies in the field, such as mechanical ventilation, anticoagulation and transfusion therapy, and ethical concerns in patients supported with VV-ECMO.",
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Fan, E, Gattinoni, L, Combes, A, Schmidt, M, Peek, G, Brodie, D, Muller, T, Morelli, A, Ranieri, VM, Pesenti, A, Brochard, L, Hodgson, C, Van Kiersbilck, C, Roch, A, Quintel, M & Papazian, L 2016, 'Venovenous extracorporeal membrane oxygenation for acute respiratory failure: A clinical review from an international group of experts', Intensive Care Medicine, vol. 42, no. 5, pp. 712-724. https://doi.org/10.1007/s00134-016-4314-7

Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts. / Fan, Eddy; Gattinoni, Luciano; Combes, Alain; Schmidt, Matthieu; Peek, Giles; Brodie, Dan; Muller, Thomas; Morelli, Andrea; Ranieri, V. Marco; Pesenti, Antonio; Brochard, Laurent; Hodgson, Carol; Van Kiersbilck, Cecile; Roch, Antoine; Quintel, Michael; Papazian, Laurent.

In: Intensive Care Medicine, Vol. 42, No. 5, 01.05.2016, p. 712-724.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Schmidt, Matthieu

AU - Peek, Giles

AU - Brodie, Dan

AU - Muller, Thomas

AU - Morelli, Andrea

AU - Ranieri, V. Marco

AU - Pesenti, Antonio

AU - Brochard, Laurent

AU - Hodgson, Carol

AU - Van Kiersbilck, Cecile

AU - Roch, Antoine

AU - Quintel, Michael

AU - Papazian, Laurent

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KW - Extracorporeal membrane oxygenation

KW - Intensive care units

KW - Respiratory distress syndrome

KW - Respiratory failure

KW - Review

KW - Adult

KW - Ventilation

KW - artificial

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JO - Intensive Care Medicine

JF - Intensive Care Medicine

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