Venoms to the rescue: Insights into the evolutionary biology of venoms are leading to therapeutic advances

Mandë Holford, Marymegan Daly, Glenn F. King, Raymond S. Norton

Research output: Contribution to journalEditorialOtherpeer-review

16 Citations (Scopus)

Abstract

Venomous animals have been admired and feared since prehistoric times, and their venoms have been used to both benefit and impair human health. In 326 BCE, Alexander the Great encountered lethal arrowheads in India that, based on the symptoms of dying soldiers, were most likely laced with venom from the deadly Russell's viper. By contrast, snake venom has been used in Ayurvedic medicine since the 7th century BCE to prolong life and treat arthritis and gastrointestinal ailments, while tarantulas are used in the traditional medicine of indigenous populations of Mexico and Central and South America. The modern era of venom research has so far yielded six venom-derived drugs. Recent work has elucidated the evolutionary biology of venoms and provided an impressive diversity of new therapeutic drug candidates.
Original languageEnglish
Pages (from-to)842-844
Number of pages3
JournalScience
Volume361
Issue number6405
DOIs
Publication statusPublished - 31 Aug 2018

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