Abstract
Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade. The therapeutic opportunities afforded by these peptides are also highlighted.
| Original language | English |
|---|---|
| Pages (from-to) | 124-138 |
| Number of pages | 15 |
| Journal | Neuropharmacology |
| Volume | 127 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- Cone snail
- Peptide
- Potassium channel
- Scorpion
- Sea anemone
- Snake
- Spider
- Therapeutic
Cite this
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Venom-derived peptide inhibitors of voltage-gated potassium channels. / Norton, Raymond S.; Chandy, K George .
In: Neuropharmacology, Vol. 127, 2017, p. 124-138.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Venom-derived peptide inhibitors of voltage-gated potassium channels
AU - Norton, Raymond S.
AU - Chandy, K George
PY - 2017
Y1 - 2017
N2 - Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade. The therapeutic opportunities afforded by these peptides are also highlighted.
AB - Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade. The therapeutic opportunities afforded by these peptides are also highlighted.
KW - Cone snail
KW - Peptide
KW - Potassium channel
KW - Scorpion
KW - Sea anemone
KW - Snake
KW - Spider
KW - Therapeutic
UR - http://www.scopus.com/inward/record.url?scp=85023629287&partnerID=8YFLogxK
U2 - 10.1016/j.neuropharm.2017.07.002
DO - 10.1016/j.neuropharm.2017.07.002
M3 - Article
VL - 127
SP - 124
EP - 138
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
ER -