Venom-derived peptide inhibitors of voltage-gated potassium channels

Raymond S. Norton, K George Chandy

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade. The therapeutic opportunities afforded by these peptides are also highlighted.

Original languageEnglish
Pages (from-to)124-138
Number of pages15
JournalNeuropharmacology
Volume127
DOIs
Publication statusPublished - 2017

Keywords

  • Cone snail
  • Peptide
  • Potassium channel
  • Scorpion
  • Sea anemone
  • Snake
  • Spider
  • Therapeutic

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