Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

E. Van Rymenant, C. Grootaert, K. Beerens, P. W. Needs, P. A. Kroon, A. Kerimi, G. Williamson, R. García-Villalba, A. González-Sarrías, F. Tomas-Barberan, J. Van Camp, J. Van de Voorde

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15 Citations (Scopus)


Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate-not their glucuronidated forms or ferulic acid-caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

Original languageEnglish
Pages (from-to)4331-4335
Number of pages5
JournalFood & Function
Issue number12
Publication statusPublished - 1 Dec 2017
Externally publishedYes

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