Vascular diseases investigated ex vivo by using Raman, FT-IR and complementary methods

Katarzyna M. Marzec, Anna Rygula, Marlena Gasior-Glogowska, Kamila Kochan, Krzysztof Czamara, Katarzyna Bulat, Kamilla Malek, Agnieszka Kaczor, Malgorzata Baranska

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Abstract

This work shows the application of vibrational spectroscopy supported by other complementary techniques in analysis of tissues altered by vascular diseases, in particular atherosclerosis. The analysis of atherosclerotic plaque components, as well as label-free imaging of vessels and identification of biochemical markers of endothelial dysfunction are reported. Additionally, the potential of vibrational spectroscopy imaging in following the disease progression (including calcification) and pathological changes in heart valves is described. The presented research shows the effectiveness of techniques used in the biochemical studies of altered tissues and summarizes their capabilities in research on vascular diseases. The scope of the paper is to collect previously published work connected with the application of Raman spectroscopy, FT-IR spectroscopy and complementary methods for the investigation of vascular diseases ex vivo and presenting it in a comprehensive overview.

Original languageEnglish
Pages (from-to)744-750
Number of pages7
JournalPharmacological Reports
Volume67
Issue number4
DOIs
Publication statusPublished - Aug 2015
Externally publishedYes

Keywords

  • Atherosclerosis
  • Atomic force microscopy
  • Infrared spectroscopy
  • Raman spectroscopy
  • Vascular diseases

Cite this

Marzec, K. M., Rygula, A., Gasior-Glogowska, M., Kochan, K., Czamara, K., Bulat, K., Malek, K., Kaczor, A., & Baranska, M. (2015). Vascular diseases investigated ex vivo by using Raman, FT-IR and complementary methods. Pharmacological Reports, 67(4), 744-750. https://doi.org/10.1016/j.pharep.2015.05.001