TY - JOUR
T1 - Vascular diseases investigated ex vivo by using Raman, FT-IR and complementary methods
AU - Marzec, Katarzyna M.
AU - Rygula, Anna
AU - Gasior-Glogowska, Marlena
AU - Kochan, Kamila
AU - Czamara, Krzysztof
AU - Bulat, Katarzyna
AU - Malek, Kamilla
AU - Kaczor, Agnieszka
AU - Baranska, Malgorzata
PY - 2015/8
Y1 - 2015/8
N2 - This work shows the application of vibrational spectroscopy supported by other complementary techniques in analysis of tissues altered by vascular diseases, in particular atherosclerosis. The analysis of atherosclerotic plaque components, as well as label-free imaging of vessels and identification of biochemical markers of endothelial dysfunction are reported. Additionally, the potential of vibrational spectroscopy imaging in following the disease progression (including calcification) and pathological changes in heart valves is described. The presented research shows the effectiveness of techniques used in the biochemical studies of altered tissues and summarizes their capabilities in research on vascular diseases. The scope of the paper is to collect previously published work connected with the application of Raman spectroscopy, FT-IR spectroscopy and complementary methods for the investigation of vascular diseases ex vivo and presenting it in a comprehensive overview.
AB - This work shows the application of vibrational spectroscopy supported by other complementary techniques in analysis of tissues altered by vascular diseases, in particular atherosclerosis. The analysis of atherosclerotic plaque components, as well as label-free imaging of vessels and identification of biochemical markers of endothelial dysfunction are reported. Additionally, the potential of vibrational spectroscopy imaging in following the disease progression (including calcification) and pathological changes in heart valves is described. The presented research shows the effectiveness of techniques used in the biochemical studies of altered tissues and summarizes their capabilities in research on vascular diseases. The scope of the paper is to collect previously published work connected with the application of Raman spectroscopy, FT-IR spectroscopy and complementary methods for the investigation of vascular diseases ex vivo and presenting it in a comprehensive overview.
KW - Atherosclerosis
KW - Atomic force microscopy
KW - Infrared spectroscopy
KW - Raman spectroscopy
KW - Vascular diseases
UR - http://www.scopus.com/inward/record.url?scp=84940462300&partnerID=8YFLogxK
U2 - 10.1016/j.pharep.2015.05.001
DO - 10.1016/j.pharep.2015.05.001
M3 - Review Article
C2 - 26321276
AN - SCOPUS:84940462300
SN - 1734-1140
VL - 67
SP - 744
EP - 750
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 4
ER -