Vascular biology and atherosclerosis of cerebral vessles

Sophocles Chrissobolis; Christopher G Sobey

Vascular biology and atherosclerosis of cerebral vessles

Sophocles Chrissobolis, Christopher G Sobey

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......

Original language	English
Title of host publication	Stroke
Subtitle of host publication	Pathophysiology, Diagnosis and Management
Editors	J C Grotta, G W Albers, J P Broderick, S E Kasner, E H Lo, A D Mendelow, R L Sacco, L O K S Wong
Place of Publication	Canada
Publisher	Elsevier
Pages	3-12
Number of pages	10
Edition	6th
ISBN (Print)	9780323295444
Publication status	Published - 2016

Cite this

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title = "Vascular biology and atherosclerosis of cerebral vessles",

abstract = "KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......",

author = "Sophocles Chrissobolis and Sobey, {Christopher G}",

year = "2016",

language = "English",

isbn = "9780323295444",

pages = "3--12",

editor = "Grotta, {J C} and Albers, {G W} and Broderick, {J P} and Kasner, {S E} and Lo, {E H} and Mendelow, {A D} and Sacco, {R L} and Wong, {L O K S}",

booktitle = "Stroke",

publisher = "Elsevier",

address = "Netherlands",

edition = "6th",

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Vascular biology and atherosclerosis of cerebral vessles. / Chrissobolis, Sophocles; Sobey, Christopher G.
Stroke: Pathophysiology, Diagnosis and Management. ed. / J C Grotta; G W Albers; J P Broderick; S E Kasner; E H Lo; A D Mendelow; R L Sacco; L O K S Wong. 6th. ed. Canada: Elsevier, 2016. p. 3-12.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

TY - CHAP

T1 - Vascular biology and atherosclerosis of cerebral vessles

AU - Chrissobolis, Sophocles

AU - Sobey, Christopher G

PY - 2016

Y1 - 2016

N2 - KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......

AB - KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......

UR - http://www.sciencedirect.com/science/book/9780323295444

M3 - Chapter (Book)

SN - 9780323295444

SP - 3

EP - 12

BT - Stroke

A2 - Grotta, J C

A2 - Albers, G W

A2 - Broderick, J P

A2 - Kasner, S E

A2 - Lo, E H

A2 - Mendelow, A D

A2 - Sacco, R L

A2 - Wong, L O K S

PB - Elsevier

CY - Canada

ER -

Vascular biology and atherosclerosis of cerebral vessles

Abstract

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