KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......
|Title of host publication||Stroke|
|Subtitle of host publication||Pathophysiology, Diagnosis and Management|
|Editors||J C Grotta, G W Albers, J P Broderick, S E Kasner, E H Lo, A D Mendelow, R L Sacco, L O K S Wong|
|Place of Publication||Canada|
|Number of pages||10|
|Publication status||Published - 2016|
Chrissobolis, S., & Sobey, C. G. (2016). Vascular biology and atherosclerosis of cerebral vessles. In J. C. Grotta, G. W. Albers, J. P. Broderick, S. E. Kasner, E. H. Lo, A. D. Mendelow, R. L. Sacco, & L. O. K. S. Wong (Eds.), Stroke: Pathophysiology, Diagnosis and Management (6th ed., pp. 3-12). Elsevier.