Vascular biology and atherosclerosis of cerebral vessles

Sophocles Chrissobolis, Christopher G Sobey

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

KEY POINTS - Cerebral artery tone is substantially modulated under physiological conditions by endothelium-derived nitric oxide, reactive oxygen species, and through hyperpolarization mediated by several types of K+ channels. - Cerebral vascular function is very sensitive to endothelial dysfunction that occurs during chronic disease, resulting in impairment of vasodilator mechanisms. - Oxidative stress and inflammation occur in the cerebral circulation in response to cardiovascular risk factors present during atherosclerosis and chronic hypertension, such as elevated plasma levels of cholesterol and angiotensin II, respectively.......
Original languageEnglish
Title of host publicationStroke
Subtitle of host publicationPathophysiology, Diagnosis and Management
EditorsJ C Grotta, G W Albers, J P Broderick, S E Kasner, E H Lo, A D Mendelow, R L Sacco, L O K S Wong
Place of PublicationCanada
PublisherElsevier
Pages3-12
Number of pages10
Edition6th
ISBN (Print)9780323295444
Publication statusPublished - 2016

Cite this

Chrissobolis, S., & Sobey, C. G. (2016). Vascular biology and atherosclerosis of cerebral vessles. In J. C. Grotta, G. W. Albers, J. P. Broderick, S. E. Kasner, E. H. Lo, A. D. Mendelow, R. L. Sacco, & L. O. K. S. Wong (Eds.), Stroke: Pathophysiology, Diagnosis and Management (6th ed., pp. 3-12). Elsevier.