Variation in the use of renal replacement therapy in patients with septic shock: a substudy of the prospective multicenter observational FINNAKI study

Meri Poukkanen, Juha Koskenkari, Suvi T Vaara, Ville Pettila, Sari Karlsson, Anna-Maija Korhonen, Jouko J Laurila, Kirsi-Maija Kaukonen, Vesa Lund, Tero Ala-Kokko

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13 Citations (Scopus)


Introduction: Indications for renal replacement therapy (RRT) have not been generally standardized and vary among intensive care units (ICUs). We aimed to assess the proportion, indications, and modality of RRT, as well as the association between the proportion of RRT use and 90-day mortality in patients with septic shock in Finnish adult ICUs.Methods: We identified patients with septic shock from the prospective observational multicenter FINNAKI study conducted between 1 September 2011 and 1 February 2012. We divided the ICUs into high-RRT and low-RRT ICUs according to the median of the proportion of RRT-treated patients with septic shock. Differences in indications, and modality of RRT between ICU groups were assessed. Finally, we performed an adjusted logistic regression analysis to evaluate the possible association of the ICU group (high vs. low-RRT) with 90-day mortality.Results: Of the 726 patients with septic shock, 131 (18.0 , 95 CI 15.2 to 20.9 ) were treated with RRT. The proportion of RRT-treated patients varied from 3 up to 36 (median 19 ) among ICUs. High-RRT ICUs included nine ICUs (354 patients) and low-RRT ICUs eight ICUs (372 patients). In the high-RRT ICUs patients with septic shock were older (P = 0.04), had more cardiovascular (P
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalCritical Care
Issue number1 (Art. No.: R26)
Publication statusPublished - 2014

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