Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

Darren M Roberts, Jason A Roberts, Michael Stephen Roberts, Xin Liu, Priya V Nair, Louise Cole, Jeff Lipman, Rinaldo Bellomo

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140 Citations (Scopus)


In critically ill patients receiving continuous renal replacement therapy, we aimed to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates on such concentrations, and the incidence of suboptimal antibiotic dosage. Design: Prospective, observational, multicenter, pharmacokinetic study. Setting: Four tertiary intensive care units within the multicenter RENAL randomized controlled trial of continuous renal replacement therapy intensity.
Original languageEnglish
Pages (from-to)1523 - 1528
Number of pages6
JournalCritical Care Medicine
Issue number5
Publication statusPublished - 2012
Externally publishedYes

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