Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

Natasha E Holmes, John D Turnidge, Wendy J Munckhof, James O Robinson, Tony Korman, Matthew VN O'Sullivan, Tara L Anderson, Sally Roberts, Sanchia J C Warren, Wei Gao, Paul D R Johnson, Benjamin Peter Howden

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)


We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.
Original languageEnglish
Pages (from-to)1163 - 1168
Number of pages6
JournalClinical Microbiology and Infection
Issue number12
Publication statusPublished - 2013

Cite this