Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus - a clinician's guide to the science informing current practice

Jean Y Lee, Benjamin Peter Howden

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Clinicians treating an infection assess a patient in terms of disease manifestation, causative organism and available antibiotic options with the aim of devising a therapeutic strategy under the creed of first, do no harm . It is often only when treatment is failing or options are limited, as in the scenario of multidrug-resistant organisms, that consideration is given to the interplay that occurs between the microbe and the host. The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin provides a prime example of these dynamic interactions. This review shall explore these concepts in relation to vancomycin for the treatment of methicillin-resistant S. aureus, with the aim of providing an informed approach to the utilization of this drug.
Original languageEnglish
Pages (from-to)855 - 869
Number of pages15
JournalExpert Review of Anti-Infective Therapy
Volume13
Issue number7
DOIs
Publication statusPublished - 2015

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