Validation of linear cerebral atrophy markers in multiple sclerosis

Helmut Butzkueven, Scott C Kolbe, Damien John Jolley, Jacqueline Y Brown, Mark J Cook, Ingrid van der Mei, P S Groom, J Carey, J Eckholdt, Justin Rubio, B V Taylor, Peter J Mitchell, Gary Francis Egan, Trevor J Kilpatrick

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    Abstract

    Linear measures of cerebral ventricular enlargement may act as surrogate measures of cerebral atrophy in multiple sclerosis (MS). Linear atrophy markers were measured from routine MRI scans during a population survey of 171 Tasmanian MS patients and 91 healthy controls. Thirty-five Victorian MS clinic patients were recruited as a validation cohort with 14 of these re-assessed 4 years later. In the population survey, we measured three linear brain atrophy markers: inter-caudate distance (ICD), third ventricle width (TVW) and frontal horn width (FHW). TVW (OR 2.0, p=0.001) and ICD (OR 16.1, p
    Original languageEnglish
    Pages (from-to)130 - 137
    Number of pages8
    JournalJournal of Clinical Neuroscience
    Volume15
    Publication statusPublished - 2008

    Cite this

    Butzkueven, H., Kolbe, S. C., Jolley, D. J., Brown, J. Y., Cook, M. J., van der Mei, I., Groom, P. S., Carey, J., Eckholdt, J., Rubio, J., Taylor, B. V., Mitchell, P. J., Egan, G. F., & Kilpatrick, T. J. (2008). Validation of linear cerebral atrophy markers in multiple sclerosis. Journal of Clinical Neuroscience, 15, 130 - 137.