Validation of linear cerebral atrophy markers in multiple sclerosis

Helmut Butzkueven, Scott C Kolbe, Damien John Jolley, Jacqueline Y Brown, Mark J Cook, Ingrid van der Mei, P S Groom, J Carey, J Eckholdt, Justin Rubio, B V Taylor, Peter J Mitchell, Gary Francis Egan, Trevor J Kilpatrick

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    Linear measures of cerebral ventricular enlargement may act as surrogate measures of cerebral atrophy in multiple sclerosis (MS). Linear atrophy markers were measured from routine MRI scans during a population survey of 171 Tasmanian MS patients and 91 healthy controls. Thirty-five Victorian MS clinic patients were recruited as a validation cohort with 14 of these re-assessed 4 years later. In the population survey, we measured three linear brain atrophy markers: inter-caudate distance (ICD), third ventricle width (TVW) and frontal horn width (FHW). TVW (OR 2.0, p=0.001) and ICD (OR 16.1, p
    Original languageEnglish
    Pages (from-to)130 - 137
    Number of pages8
    JournalJournal of Clinical Neuroscience
    Publication statusPublished - 2008

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