Validation of an echocardiographic assessment of cardiac function following moderate size myocardial infarction in the rat

Louise M. Burrell, Robert Chan, Paddy A. Phillips, Paul Calafiore, Andrew M. Tonkin, Colin I. Johnston

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1. The present study determined whether two dimensional guided M-mode echocardiography could assess left ventricular (LV) geometry and function following a moderate size myocardial infarction in the rat. 2. Myocardial infarction (MI) was induced by left coronary artery ligation and rats were studied 4 weeks later. Infarct rats showed increased LV internal diastolic diameter (7.33 ± 0.8 vs 5.91 ± 0.6 mm; P<0.001), LV systolic diameter (3.73 ± 1.2 vs 1.87 ± 0.6 mm; P < 0.001) and thickening of the noninfarcted posterior wall compared with sham operated rats (1.81 ± 0.2 vs 1.47 ± 0.3; P<0.001; n = 10/group; mean ± s.d.). Systolic function was impaired in infarct rats who showed reduced fractional shortening (50 ± 12 vs 68 ± 9%; P<0.001) and fractional area change (41 ± 14 vs 78 ± 5%; P<0.001). Infarct size measured echocardiographically was comparable to that measured by quantitative histological examination (29 ± 10 vs 28 ± 5%; NS). 3. The present study indicates that postinfarction remodelling leading to LV cavity dilation, hypertrophy of surviving myocardium and impaired systolic function is apparent 4 weeks following moderate size MI in the rat. 4. Transthoracic echocardiography is a noninvasive technique that may be used to assess serially the efficacy of therapeutic interventions designed to prevent remodelling in moderate size MI in the rat.

Original languageEnglish
Pages (from-to)570-572
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Issue number6-7
Publication statusPublished - Jul 1996
Externally publishedYes


  • echocardiography
  • hypertrophy
  • left ventricle
  • myocardial infarction

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