Abstract
Paradoxical stable entrainment of heart rate to inhibitory impulses can be simulated with two distinct mathematical models; a complex ionic current model of sinoartrial node pacemaker activity, as well as a simple integrator with non-linear feedback. We show that both models exhibit similar entrainment characteristics to repetitive vagal stimuli. By applying a sharp disturbance to each model whilst entrained, the subsequent path of cycle length recovery can be described by dynamic phase response curves and phase-phase plots, the properties of which dictate whether stable entrainment is possible.
Original language | English |
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Pages (from-to) | 86-94 |
Number of pages | 9 |
Journal | Australasian Physical and Engineering Sciences in Medicine |
Volume | 24 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Jan 2001 |
Externally published | Yes |
Keywords
- Entrainment
- Modelling
- Sinoatrial node
- Vagal stimulus