Paradoxical stable entrainment of heart rate to inhibitory impulses can be simulated with two distinct mathematical models; a complex ionic current model of sinoartrial node pacemaker activity, as well as a simple integrator with non-linear feedback. We show that both models exhibit similar entrainment characteristics to repetitive vagal stimuli. By applying a sharp disturbance to each model whilst entrained, the subsequent path of cycle length recovery can be described by dynamic phase response curves and phase-phase plots, the properties of which dictate whether stable entrainment is possible.
|Number of pages||9|
|Journal||Australasian Physical and Engineering Sciences in Medicine|
|Publication status||Published - 1 Jan 2001|
- Sinoatrial node
- Vagal stimulus