Vaccines against leptospirosis

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Abstract

Vaccines against leptospirosis followed within a year of the first isolation of Leptospira, with the first use of a killed whole cell bacterin vaccine in guinea pigs published in 1916. Since then, bacterin vaccines have been used in humans, cattle, swine, and dogs and remain the only vaccines licensed at the present time. The immunity elicited is restricted to serovars with related lipopolysaccharide (LPS) antigen. Likewise, vaccines based on LPS antigens have clearly demonstrated protection in animal models, which is also at best serogroup specific. The advent of leptospiral genome sequences has allowed a reverse vaccinology approach for vaccine development. However, the use of inadequate challenge doses and inappropriate statistical analysis invalidates many of the claims of protection with recombinant proteins.
Original languageEnglish
Title of host publicationLeptospira and Leptospirosis
EditorsBen Adler
Place of PublicationGermany
PublisherSpringer
Pages251-272
Number of pages22
Edition1st
ISBN (Electronic)978-3-662-45059-8
ISBN (Print)978-3-662-45058-1
DOIs
Publication statusPublished - 2015

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume387
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

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