TY - CHAP
T1 - Vaccines against leptospirosis
AU - Adler, Ben
PY - 2015
Y1 - 2015
N2 - Vaccines against leptospirosis followed within a year of the first isolation of Leptospira, with the first use of a killed whole cell bacterin vaccine in guinea pigs published in 1916. Since then, bacterin vaccines have been used in humans, cattle, swine, and dogs and remain the only vaccines licensed at the present time. The immunity elicited is restricted to serovars with related lipopolysaccharide (LPS) antigen. Likewise, vaccines based on LPS antigens have clearly demonstrated protection in animal models, which is also at best serogroup specific. The advent of leptospiral genome sequences has allowed a reverse vaccinology approach for vaccine development. However, the use of inadequate challenge doses and inappropriate statistical analysis invalidates many of the claims of protection with recombinant proteins.
AB - Vaccines against leptospirosis followed within a year of the first isolation of Leptospira, with the first use of a killed whole cell bacterin vaccine in guinea pigs published in 1916. Since then, bacterin vaccines have been used in humans, cattle, swine, and dogs and remain the only vaccines licensed at the present time. The immunity elicited is restricted to serovars with related lipopolysaccharide (LPS) antigen. Likewise, vaccines based on LPS antigens have clearly demonstrated protection in animal models, which is also at best serogroup specific. The advent of leptospiral genome sequences has allowed a reverse vaccinology approach for vaccine development. However, the use of inadequate challenge doses and inappropriate statistical analysis invalidates many of the claims of protection with recombinant proteins.
UR - http://link.springer.com/chapter/10.1007%2F978-3-662-45059-8_10
U2 - 10.1007/978-3-662-45059-8_10
DO - 10.1007/978-3-662-45059-8_10
M3 - Chapter (Book)
SN - 9783662450581
T3 - Current Topics in Microbiology and Immunology
SP - 251
EP - 272
BT - Leptospira and Leptospirosis
A2 - Adler, Ben
PB - Springer
CY - Germany
ER -