Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men

I. Mary Poynten, Sepehr N. Tabrizi, Fengyi Jin, David J. Templeton, Dorothy A. Machalek, Alyssa Cornall, Samuel Phillips, Christopher K. Fairley, Suzanne M. Garland, Carmella Law, Andrew Carr, Richard J. Hillman, Andrew E. Grulich

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM. Methods The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status. Results Anal HPV results from 606 (98.2%) of 617 participants (median age 49 years, 35.7% HIV-positive) showed 525 (86.7%) had ≥1 HPV type and 178 (29.4%) had HPV16. Over one third of participants (214, 35.3%) had no nonavalent vaccine-preventable types detected. Two (0.3%) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0.001) and younger participants (p=0.059) were more likely to have more vaccine-preventable HPV types detected. Conclusion Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalPapillomavirus Research
Volume3
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Anal
  • Gay and bisexual men
  • HIV
  • HPV
  • Human papillomavirus
  • MSM
  • Prevalence
  • Vaccine

Cite this

Poynten, I. M., Tabrizi, S. N., Jin, F., Templeton, D. J., Machalek, D. A., Cornall, A., ... Grulich, A. E. (2017). Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men. Papillomavirus Research, 3, 80-84. https://doi.org/10.1016/j.pvr.2017.02.003
Poynten, I. Mary ; Tabrizi, Sepehr N. ; Jin, Fengyi ; Templeton, David J. ; Machalek, Dorothy A. ; Cornall, Alyssa ; Phillips, Samuel ; Fairley, Christopher K. ; Garland, Suzanne M. ; Law, Carmella ; Carr, Andrew ; Hillman, Richard J. ; Grulich, Andrew E. / Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men. In: Papillomavirus Research. 2017 ; Vol. 3. pp. 80-84.
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title = "Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men",
abstract = "Objective HPV causes ~90{\%} of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM. Methods The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status. Results Anal HPV results from 606 (98.2{\%}) of 617 participants (median age 49 years, 35.7{\%} HIV-positive) showed 525 (86.7{\%}) had ≥1 HPV type and 178 (29.4{\%}) had HPV16. Over one third of participants (214, 35.3{\%}) had no nonavalent vaccine-preventable types detected. Two (0.3{\%}) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0.001) and younger participants (p=0.059) were more likely to have more vaccine-preventable HPV types detected. Conclusion Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored.",
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Poynten, IM, Tabrizi, SN, Jin, F, Templeton, DJ, Machalek, DA, Cornall, A, Phillips, S, Fairley, CK, Garland, SM, Law, C, Carr, A, Hillman, RJ & Grulich, AE 2017, 'Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men' Papillomavirus Research, vol. 3, pp. 80-84. https://doi.org/10.1016/j.pvr.2017.02.003

Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men. / Poynten, I. Mary; Tabrizi, Sepehr N.; Jin, Fengyi; Templeton, David J.; Machalek, Dorothy A.; Cornall, Alyssa; Phillips, Samuel; Fairley, Christopher K.; Garland, Suzanne M.; Law, Carmella; Carr, Andrew; Hillman, Richard J.; Grulich, Andrew E.

In: Papillomavirus Research, Vol. 3, 01.06.2017, p. 80-84.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men

AU - Poynten, I. Mary

AU - Tabrizi, Sepehr N.

AU - Jin, Fengyi

AU - Templeton, David J.

AU - Machalek, Dorothy A.

AU - Cornall, Alyssa

AU - Phillips, Samuel

AU - Fairley, Christopher K.

AU - Garland, Suzanne M.

AU - Law, Carmella

AU - Carr, Andrew

AU - Hillman, Richard J.

AU - Grulich, Andrew E.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Objective HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM. Methods The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status. Results Anal HPV results from 606 (98.2%) of 617 participants (median age 49 years, 35.7% HIV-positive) showed 525 (86.7%) had ≥1 HPV type and 178 (29.4%) had HPV16. Over one third of participants (214, 35.3%) had no nonavalent vaccine-preventable types detected. Two (0.3%) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0.001) and younger participants (p=0.059) were more likely to have more vaccine-preventable HPV types detected. Conclusion Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored.

AB - Objective HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM. Methods The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status. Results Anal HPV results from 606 (98.2%) of 617 participants (median age 49 years, 35.7% HIV-positive) showed 525 (86.7%) had ≥1 HPV type and 178 (29.4%) had HPV16. Over one third of participants (214, 35.3%) had no nonavalent vaccine-preventable types detected. Two (0.3%) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0.001) and younger participants (p=0.059) were more likely to have more vaccine-preventable HPV types detected. Conclusion Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored.

KW - Anal

KW - Gay and bisexual men

KW - HIV

KW - HPV

KW - Human papillomavirus

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KW - Prevalence

KW - Vaccine

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Poynten IM, Tabrizi SN, Jin F, Templeton DJ, Machalek DA, Cornall A et al. Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men. Papillomavirus Research. 2017 Jun 1;3:80-84. https://doi.org/10.1016/j.pvr.2017.02.003