Vaccination against hydatidosis using a defined recombinant antigen

M. W. Lightowlers; S. B. Lawrence; C. G. Gauci; J. Young; M. J. Ralston; D. Maas; D. D. Heath

doi:10.1111/j.1365-3024.1996.tb01029.x

Vaccination against hydatidosis using a defined recombinant antigen

M. W. Lightowlers, S. B. Lawrence, C. G. Gauci, J. Young, M. J. Ralston, D. Maas, D. D. Heath

Research output: Contribution to journal › Article › Research › peer-review

188 Citations (Scopus)

Abstract

Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an urgent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.

Original language	English
Pages (from-to)	457-462
Number of pages	6
Journal	Parasite Immunology
Volume	18
Issue number	9
DOIs	https://doi.org/10.1111/j.1365-3024.1996.tb01029.x
Publication status	Published - Sept 1996
Externally published	Yes

Keywords

Echinococcosis
Echinococcus granulosus
Hydatid
Recombinant antigen
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3024.1996.tb01029.x

Cite this

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title = "Vaccination against hydatidosis using a defined recombinant antigen",

abstract = "Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an urgent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.",

keywords = "Echinococcosis, Echinococcus granulosus, Hydatid, Recombinant antigen, Vaccine",

author = "Lightowlers, {M. W.} and Lawrence, {S. B.} and Gauci, {C. G.} and J. Young and Ralston, {M. J.} and D. Maas and Heath, {D. D.}",

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language = "English",

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T1 - Vaccination against hydatidosis using a defined recombinant antigen

AU - Lightowlers, M. W.

AU - Lawrence, S. B.

AU - Gauci, C. G.

AU - Young, J.

AU - Ralston, M. J.

AU - Maas, D.

AU - Heath, D. D.

PY - 1996/9

Y1 - 1996/9

N2 - Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an urgent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.

AB - Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an urgent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.

KW - Echinococcosis

KW - Echinococcus granulosus

KW - Hydatid

KW - Recombinant antigen

KW - Vaccine

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U2 - 10.1111/j.1365-3024.1996.tb01029.x

DO - 10.1111/j.1365-3024.1996.tb01029.x

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AN - SCOPUS:0029746247

SN - 0141-9838

VL - 18

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EP - 462

JO - Parasite Immunology

JF - Parasite Immunology

IS - 9

ER -

Vaccination against hydatidosis using a defined recombinant antigen

Abstract

Keywords

UN SDGs

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