TY - JOUR
T1 - Utilization of peroxide reduction reaction at air–liquid–solid joint interfaces for reliable sensing system construction
AU - Song, Zhiqian
AU - Xu, Chenlong
AU - Sheng, Xia
AU - Feng, Xinjian
AU - Jiang, Lei
PY - 2018/2/8
Y1 - 2018/2/8
N2 - The utilization of hydrogen peroxide (H2O2) cathodic reaction is an ideal approach to develop reliable biosensors that are immune to interferences arising from oxidizable endogenous/exogenous species in biological solutions. However, practical application of such a detection scheme is limited due to the significantly fluctuating oxygen levels in solutions, as oxygen can be reduced at similar potentials. Herein, this limitation is addressed by developing a novel electrode system with superhydrophobicity-mediated air–liquid–solid joint interfaces, which allows the rapid and continuous transport of oxygen from the air phase to the electrode surface and provides a fixed interfacial oxygen concentration. Using cathodic measurement of the enzymatic product H2O2, the sensing platform is applied to detect glucose, a model analyte, achieving a remarkably high selectivity (≈2% signal modulation due to common biologic interferents), sensitivity (18.56 µA cm−2 mm−1), and a dynamic linear range up to 80 × 10−3m. The utility of H2O2 reduction reaction at triphase interface to achieve reliable sensing platforms is general, and hence has broad potential in the fields of medical research, clinical diagnosis, and environmental analysis.
AB - The utilization of hydrogen peroxide (H2O2) cathodic reaction is an ideal approach to develop reliable biosensors that are immune to interferences arising from oxidizable endogenous/exogenous species in biological solutions. However, practical application of such a detection scheme is limited due to the significantly fluctuating oxygen levels in solutions, as oxygen can be reduced at similar potentials. Herein, this limitation is addressed by developing a novel electrode system with superhydrophobicity-mediated air–liquid–solid joint interfaces, which allows the rapid and continuous transport of oxygen from the air phase to the electrode surface and provides a fixed interfacial oxygen concentration. Using cathodic measurement of the enzymatic product H2O2, the sensing platform is applied to detect glucose, a model analyte, achieving a remarkably high selectivity (≈2% signal modulation due to common biologic interferents), sensitivity (18.56 µA cm−2 mm−1), and a dynamic linear range up to 80 × 10−3m. The utility of H2O2 reduction reaction at triphase interface to achieve reliable sensing platforms is general, and hence has broad potential in the fields of medical research, clinical diagnosis, and environmental analysis.
KW - peroxide reduction reaction
KW - selectivity
KW - sensing systems
KW - triphase interface
UR - http://www.scopus.com/inward/record.url?scp=85039049265&partnerID=8YFLogxK
U2 - 10.1002/adma.201701473
DO - 10.1002/adma.201701473
M3 - Article
C2 - 29280206
AN - SCOPUS:85039049265
VL - 30
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 6
M1 - 1701473
ER -