Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases

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2 Citations (Scopus)

Abstract

BACKGROUND: The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery.

METHODS: A retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined. Pre-operative PET/CT scans were reviewed by two experienced nuclear medicine physicians and SUVmax of the largest node in each nodal basin documented. These were compared with the histology results of the neck dissection.

RESULTS: A total of 359 nodal basins including 86 basins with metastatic nodes were evaluated. A nodal SUVmax ≥3.16 yielded a sensitivity of 74.4 % and specificity of 84.9 % in detecting metastatic nodes. The nodal SUVmax/Liver SUVmax ratio was found on receiver operating characteristic (ROC) to be effective in detecting metastatic nodes with an area under ROC curve of 0.90. A nodal SUVmax/Liver SUVmax ratio ≥0.90 yielded a sensitivity of 74.1 % and specificity of 93.4 %. By comparison, visual inspection yielded sensitivities of 66.3 and 61.6 % in observers 1 and 2 respectively. The corresponding specificities were 77.7 and 86.5 %.

CONCLUSIONS: Nodal SUVmax and nodal SUVmax/liver SUVmax are both useful in the pre-operative detection of metastatic nodes with the latter being superior to visual inspection. The ratio is likely to be more useful as it corrects for inter-scanner variability.

Original languageEnglish
Article number39
Pages (from-to)1-8
Number of pages8
JournalCancer Imaging
Volume16
Issue number1
DOIs
Publication statusPublished - 8 Nov 2016

Keywords

  • Lymphadenopathy
  • Metastasis
  • Positron emission tomography (PET)
  • Squamous cell carcinoma
  • Standardized uptake value

Cite this

@article{f75ed03c082a46a8aa49aeb2399b2767,
title = "Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases",
abstract = "BACKGROUND: The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery.METHODS: A retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined. Pre-operative PET/CT scans were reviewed by two experienced nuclear medicine physicians and SUVmax of the largest node in each nodal basin documented. These were compared with the histology results of the neck dissection.RESULTS: A total of 359 nodal basins including 86 basins with metastatic nodes were evaluated. A nodal SUVmax ≥3.16 yielded a sensitivity of 74.4 {\%} and specificity of 84.9 {\%} in detecting metastatic nodes. The nodal SUVmax/Liver SUVmax ratio was found on receiver operating characteristic (ROC) to be effective in detecting metastatic nodes with an area under ROC curve of 0.90. A nodal SUVmax/Liver SUVmax ratio ≥0.90 yielded a sensitivity of 74.1 {\%} and specificity of 93.4 {\%}. By comparison, visual inspection yielded sensitivities of 66.3 and 61.6 {\%} in observers 1 and 2 respectively. The corresponding specificities were 77.7 and 86.5 {\%}.CONCLUSIONS: Nodal SUVmax and nodal SUVmax/liver SUVmax are both useful in the pre-operative detection of metastatic nodes with the latter being superior to visual inspection. The ratio is likely to be more useful as it corrects for inter-scanner variability.",
keywords = "Lymphadenopathy, Metastasis, Positron emission tomography (PET), Squamous cell carcinoma, Standardized uptake value",
author = "Lim, {Rebecca S. M.} and Shakher Ramdave and Paul Beech and Baki Billah and Karim, {Md Nazmul} and Smith, {Julian A.} and Adnan Safdar and Elizabeth Sigston",
year = "2016",
month = "11",
day = "8",
doi = "10.1186/s40644-016-0095-z",
language = "English",
volume = "16",
pages = "1--8",
journal = "Cancer Imaging",
issn = "1470-7330",
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}

Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases. / Lim, Rebecca S. M.; Ramdave, Shakher; Beech, Paul; Billah, Baki; Karim, Md Nazmul; Smith, Julian A.; Safdar, Adnan; Sigston, Elizabeth.

In: Cancer Imaging, Vol. 16, No. 1, 39, 08.11.2016, p. 1-8.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases

AU - Lim, Rebecca S. M.

AU - Ramdave, Shakher

AU - Beech, Paul

AU - Billah, Baki

AU - Karim, Md Nazmul

AU - Smith, Julian A.

AU - Safdar, Adnan

AU - Sigston, Elizabeth

PY - 2016/11/8

Y1 - 2016/11/8

N2 - BACKGROUND: The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery.METHODS: A retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined. Pre-operative PET/CT scans were reviewed by two experienced nuclear medicine physicians and SUVmax of the largest node in each nodal basin documented. These were compared with the histology results of the neck dissection.RESULTS: A total of 359 nodal basins including 86 basins with metastatic nodes were evaluated. A nodal SUVmax ≥3.16 yielded a sensitivity of 74.4 % and specificity of 84.9 % in detecting metastatic nodes. The nodal SUVmax/Liver SUVmax ratio was found on receiver operating characteristic (ROC) to be effective in detecting metastatic nodes with an area under ROC curve of 0.90. A nodal SUVmax/Liver SUVmax ratio ≥0.90 yielded a sensitivity of 74.1 % and specificity of 93.4 %. By comparison, visual inspection yielded sensitivities of 66.3 and 61.6 % in observers 1 and 2 respectively. The corresponding specificities were 77.7 and 86.5 %.CONCLUSIONS: Nodal SUVmax and nodal SUVmax/liver SUVmax are both useful in the pre-operative detection of metastatic nodes with the latter being superior to visual inspection. The ratio is likely to be more useful as it corrects for inter-scanner variability.

AB - BACKGROUND: The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery.METHODS: A retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined. Pre-operative PET/CT scans were reviewed by two experienced nuclear medicine physicians and SUVmax of the largest node in each nodal basin documented. These were compared with the histology results of the neck dissection.RESULTS: A total of 359 nodal basins including 86 basins with metastatic nodes were evaluated. A nodal SUVmax ≥3.16 yielded a sensitivity of 74.4 % and specificity of 84.9 % in detecting metastatic nodes. The nodal SUVmax/Liver SUVmax ratio was found on receiver operating characteristic (ROC) to be effective in detecting metastatic nodes with an area under ROC curve of 0.90. A nodal SUVmax/Liver SUVmax ratio ≥0.90 yielded a sensitivity of 74.1 % and specificity of 93.4 %. By comparison, visual inspection yielded sensitivities of 66.3 and 61.6 % in observers 1 and 2 respectively. The corresponding specificities were 77.7 and 86.5 %.CONCLUSIONS: Nodal SUVmax and nodal SUVmax/liver SUVmax are both useful in the pre-operative detection of metastatic nodes with the latter being superior to visual inspection. The ratio is likely to be more useful as it corrects for inter-scanner variability.

KW - Lymphadenopathy

KW - Metastasis

KW - Positron emission tomography (PET)

KW - Squamous cell carcinoma

KW - Standardized uptake value

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U2 - 10.1186/s40644-016-0095-z

DO - 10.1186/s40644-016-0095-z

M3 - Article

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JF - Cancer Imaging

SN - 1470-7330

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