@inbook{64a9e1b47c4f4bffb07995ce17dc0fc1,
title = "Utility of endoscopic ultrasound-guided fine-needle aspiration for preclinical evaluation of therapies in cancer",
abstract = "Personalising cancer therapy is a way of improving treatment efficacy, by selecting specific treatments for patients with certain molecular changes to their tumour. This requires both molecular material to detect these targets and a preclinical disease model to demonstrate treatment efficacy. In pancreatic cancer this is problematic, as most patients present with advanced disease and are therefore ineligible for surgery. As a result, biological material derived from such patients has been excluded from all preclinical studies in personalised medicine. This chapter presents methodology to achieve both of the above-mentioned requirements using endoscopic ultrasound-guided fine-needle aspiration, which can be offered to nearly all patients with early or advanced disease.",
keywords = "EUS-FNA, NOD-SCID mice, Oncology, Pancreatic cancer, Personalised therapy, RNA, RNAseq, Target therapy, Xenograft",
author = "William Berry and Daniel Croagh",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-7568-6_3",
language = "English",
isbn = "9781493975679",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "31--40",
editor = "{ Jenkins}, {Brendan J.}",
booktitle = "Inflammation and Cancer",
address = "United States of America",
}
