Uterine artery doppler in screening for preeclampsia and fetal growth restriction

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Objective To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. Methods A search of the literature was conducted usingMedline, PubMed, MeSH and ScienceDirect. Combinations of the search terms “preeclampsia,” “screening,” “prediction,” “Doppler,” “Doppler velocimetry,” “fetal growth restriction,” “small for gestational age” and “uterine artery” were used. Articles in English (excluding reviews) reporting the use of uterine artery Doppler in screening for PE and FGR were included. Results Thirty articles were included. As a single predictor, uterine artery Doppler detects less than 50% of the cases of PE and no more than 40% of the pregnancies affected by FGR. Logistic regression-based models that allow calculation of individual risk based on the combination of multiple markers, in turn, is able to detect _ 75% of the cases of preterm PE and 55% of the pregnancies resulting in small for gestational age infants. Conclusion The use of uterine artery Doppler as a single predictive test for PE and FGR has poor accuracy. However, its combined use in predictive models is promising, being more accurate in detecting preterm PE than FGR.

Translated title of the contributionUterine artery doppler in screening for preeclampsia and fetal growth restriction
Original languagePortuguese
Pages (from-to)287-293
Number of pages7
JournalRevista Brasileira de Ginecologia e Obstetricia
Volume40
Issue number5
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Doppler
  • Fetal growth restriction
  • Preeclampsia
  • Screening
  • Uterine arteries

Cite this

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title = "Doppler das art{\'e}rias uterinas no rastreamento para pr{\'e}-ecl{\^a}mpsia e restri{\cc}{\~a}o do crescimento fetal",
abstract = "Objective To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. Methods A search of the literature was conducted usingMedline, PubMed, MeSH and ScienceDirect. Combinations of the search terms “preeclampsia,” “screening,” “prediction,” “Doppler,” “Doppler velocimetry,” “fetal growth restriction,” “small for gestational age” and “uterine artery” were used. Articles in English (excluding reviews) reporting the use of uterine artery Doppler in screening for PE and FGR were included. Results Thirty articles were included. As a single predictor, uterine artery Doppler detects less than 50{\%} of the cases of PE and no more than 40{\%} of the pregnancies affected by FGR. Logistic regression-based models that allow calculation of individual risk based on the combination of multiple markers, in turn, is able to detect _ 75{\%} of the cases of preterm PE and 55{\%} of the pregnancies resulting in small for gestational age infants. Conclusion The use of uterine artery Doppler as a single predictive test for PE and FGR has poor accuracy. However, its combined use in predictive models is promising, being more accurate in detecting preterm PE than FGR.",
keywords = "Doppler, Fetal growth restriction, Preeclampsia, Screening, Uterine arteries",
author = "Pedroso, {Marianna Amaral} and Palmer, {Kirsten Rebecca} and Hodges, {Ryan James} and Costa, {Fabricio da Silva} and Rolnik, {Daniel Lorber}",
year = "2018",
month = "5",
day = "1",
doi = "10.1055/s-0038-1660777",
language = "Portuguese",
volume = "40",
pages = "287--293",
journal = "Revista Brasileira de Ginecologia e Obstetricia",
issn = "0100-7203",
publisher = "Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (FEBRASGO)",
number = "5",

}

TY - JOUR

T1 - Doppler das artérias uterinas no rastreamento para pré-eclâmpsia e restrição do crescimento fetal

AU - Pedroso, Marianna Amaral

AU - Palmer, Kirsten Rebecca

AU - Hodges, Ryan James

AU - Costa, Fabricio da Silva

AU - Rolnik, Daniel Lorber

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Objective To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. Methods A search of the literature was conducted usingMedline, PubMed, MeSH and ScienceDirect. Combinations of the search terms “preeclampsia,” “screening,” “prediction,” “Doppler,” “Doppler velocimetry,” “fetal growth restriction,” “small for gestational age” and “uterine artery” were used. Articles in English (excluding reviews) reporting the use of uterine artery Doppler in screening for PE and FGR were included. Results Thirty articles were included. As a single predictor, uterine artery Doppler detects less than 50% of the cases of PE and no more than 40% of the pregnancies affected by FGR. Logistic regression-based models that allow calculation of individual risk based on the combination of multiple markers, in turn, is able to detect _ 75% of the cases of preterm PE and 55% of the pregnancies resulting in small for gestational age infants. Conclusion The use of uterine artery Doppler as a single predictive test for PE and FGR has poor accuracy. However, its combined use in predictive models is promising, being more accurate in detecting preterm PE than FGR.

AB - Objective To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. Methods A search of the literature was conducted usingMedline, PubMed, MeSH and ScienceDirect. Combinations of the search terms “preeclampsia,” “screening,” “prediction,” “Doppler,” “Doppler velocimetry,” “fetal growth restriction,” “small for gestational age” and “uterine artery” were used. Articles in English (excluding reviews) reporting the use of uterine artery Doppler in screening for PE and FGR were included. Results Thirty articles were included. As a single predictor, uterine artery Doppler detects less than 50% of the cases of PE and no more than 40% of the pregnancies affected by FGR. Logistic regression-based models that allow calculation of individual risk based on the combination of multiple markers, in turn, is able to detect _ 75% of the cases of preterm PE and 55% of the pregnancies resulting in small for gestational age infants. Conclusion The use of uterine artery Doppler as a single predictive test for PE and FGR has poor accuracy. However, its combined use in predictive models is promising, being more accurate in detecting preterm PE than FGR.

KW - Doppler

KW - Fetal growth restriction

KW - Preeclampsia

KW - Screening

KW - Uterine arteries

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