Using zebrafish to study human genetic disease

Jan Kaslin, Yann Gibert

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Abstract

Zebrafish is becoming a more and more popular model organism to study human genetic disease. Recent advances in genome editing, including but not limited to the CRISPR/cas technology, have made zebrafish model one of the fastest, cheapest and easiest model to generate mutations similar to the ones identified in human genetic disorders. Based on its size, zebrafish mutant embryos are also a perfect model to be used in chemical preclinical screens to identify novel molecules that are able to compensate for the partial or total inactivation of a gene. Progress in human genome sequencing has recently identified several novel alleles linked to genetic disorders that can now be tested for the identification of novel therapeutics in a zebrafish mutant modelled to phenocopy the human mutation.
Original languageEnglish
Title of host publicationeLS
Subtitle of host publicationEncyclopedia of Life Sciences
PublisherJohn Wiley & Sons
Number of pages8
ISBN (Electronic)9780470015902
ISBN (Print)9780470016176
DOIs
Publication statusPublished - 31 Oct 2017

Cite this

Kaslin, J., & Gibert, Y. (2017). Using zebrafish to study human genetic disease. In eLS: Encyclopedia of Life Sciences John Wiley & Sons. https://doi.org/10.1002/9780470015902.a0027226