Using Stimulus-Response Curves to Determine Corticospinal Excitability

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The excitability of the corticospinal tract can be quantified through the application of single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) and simultaneously recording the neurophysiological response at the target muscle through electromyography (EMG). In this chapter, we introduce the technique for constructing stimulusresponse (S-R) curves and the common methods employed to characterise the input-output properties of the corticospinal tract. We then describe the neurophysiological correlates of S-R curves and the physiological factors that can influence the TMS responses during the construction of an S-R curve, including age.
Original languageEnglish
Title of host publicationA Closer Look at Motor-Evoked Potential
EditorsShapour Jaberzadeh
Place of PublicationHauppauge NY USA
PublisherNova Science Publishers
Number of pages15
ISBN (Electronic)9781536143904
ISBN (Print)9781536143898
Publication statusPublished - Jan 2019


  • input-output curve
  • corticospinal excitability
  • inhibition
  • motor cortex
  • motor evoked potential

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