Using steric bulk for selective recognition; Blocking the binding site to differentiate guests

Ryan N. Robson, Frederick M. Pfeffer

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)


Selectivity is demonstrated in a supramolecular host:guest system using a receptor with a non-linear binding site. For the "open" receptor 1 strong binding for both flexible and rigid guests was observed. Receptor 2, with a "blocked" binding site, also bound flexible guests effectively but its affinity for rigid guests was 50 fold lower.

Original languageEnglish
Pages (from-to)8719-8721
Number of pages3
JournalChemical Communications
Issue number56
Publication statusPublished - 18 Jul 2016
Externally publishedYes

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