Using physiology to guide time to cord clamping

Martin Kluckow, Stuart Brian Hooper

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)


Immediate clamping and cutting of the umbilical cord at birth has been the accepted standard of care for decades. The physiologic rationale relating umbilical cord clamping (UCC) to the events of the circulatory transition is not considered in arbitrarily recommended cord clamping times. Systematic review of early versus deferred UCC shows significant hemodynamic benefits to the deferred group. Mechanisms for this protective effect are considered in this review. The original concept of a placental transfusion with a volume load and prevention of low cardiac output relies on the physiological end point of the amount of blood transfused. The newer concept of an ordered physiological transition is increasingly supported. This model places aeration of the lungs and an increase in pulmonary blood flow back at the centre of the circulatory transition with timing of UCC being related to establishment of respiration. The need for physiologically based UCC is discussed.
Original languageEnglish
Pages (from-to)225 - 231
Number of pages7
JournalSeminars in Fetal and Neonatal Medicine
Issue number4
Publication statusPublished - 2015

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