Abstract
| Original language | English |
|---|---|
| Title of host publication | Physics Procedia |
| Subtitle of host publication | Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14 |
| Editors | Nico Felicien Declercq de Patin |
| Place of Publication | Amsterdam, Netherlands |
| Publisher | Elsevier |
| Pages | 18-20 |
| Number of pages | 3 |
| Volume | 70 |
| DOIs | |
| Publication status | Published - 2015 |
| Event | International Congress on Ultrasonics - Metz, France Duration: 10 May 2015 → 14 May 2015 |
Conference
| Conference | International Congress on Ultrasonics |
|---|---|
| Country | France |
| City | Metz |
| Period | 10/05/15 → 14/05/15 |
Keywords
- Ultrasonics
- Acoustic streaming
- Surface acoustic waves
- Malaria
Cite this
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Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. / Sivanantha, Ninnuja; Ma, Charles; Collins, David J.; Sesen, Muhsincan; Brenker, Jason; Coppel, Ross L.; Neild, Adrian; Alan, Tuncay.
Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. ed. / Nico Felicien Declercq de Patin. Vol. 70 Amsterdam, Netherlands : Elsevier, 2015. p. 18-20.Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review
TY - GEN
T1 - Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells
AU - Sivanantha, Ninnuja
AU - Ma, Charles
AU - Collins, David J.
AU - Sesen, Muhsincan
AU - Brenker, Jason
AU - Coppel, Ross L.
AU - Neild, Adrian
AU - Alan, Tuncay
PY - 2015
Y1 - 2015
N2 - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
AB - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
KW - Ultrasonics
KW - Acoustic streaming
KW - Surface acoustic waves
KW - Malaria
UR - http://www.scopus.com/inward/record.url?scp=84948666092&partnerID=8YFLogxK
U2 - 10.1016/j.phpro.2015.08.016
DO - 10.1016/j.phpro.2015.08.016
M3 - Conference Paper
VL - 70
SP - 18
EP - 20
BT - Physics Procedia
A2 - Declercq de Patin, Nico Felicien
PB - Elsevier
CY - Amsterdam, Netherlands
ER -