Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

Ninnuja Sivanantha, Charles Ma, David J. Collins, Muhsincan Sesen, Jason Brenker, Ross L. Coppel, Adrian Neild, Tuncay Alan

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
Original languageEnglish
Title of host publicationPhysics Procedia
Subtitle of host publicationProceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14
EditorsNico Felicien Declercq de Patin
Place of PublicationAmsterdam, Netherlands
PublisherElsevier
Pages18-20
Number of pages3
Volume70
DOIs
Publication statusPublished - 2015
EventInternational Congress on Ultrasonics - Metz, France
Duration: 10 May 201514 May 2015

Conference

ConferenceInternational Congress on Ultrasonics
CountryFrance
CityMetz
Period10/05/1514/05/15

Keywords

  • Ultrasonics
  • Acoustic streaming
  • Surface acoustic waves
  • Malaria

Cite this

Sivanantha, N., Ma, C., Collins, D. J., Sesen, M., Brenker, J., Coppel, R. L., ... Alan, T. (2015). Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. In N. F. Declercq de Patin (Ed.), Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14 (Vol. 70, pp. 18-20). Amsterdam, Netherlands: Elsevier. https://doi.org/10.1016/j.phpro.2015.08.016
Sivanantha, Ninnuja ; Ma, Charles ; Collins, David J. ; Sesen, Muhsincan ; Brenker, Jason ; Coppel, Ross L. ; Neild, Adrian ; Alan, Tuncay. / Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. editor / Nico Felicien Declercq de Patin. Vol. 70 Amsterdam, Netherlands : Elsevier, 2015. pp. 18-20
@inproceedings{d1ce1ea234f84e4abb066629e06f3eaf,
title = "Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells",
abstract = "A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79{\%} difference in cell mobilization between healthy malaria infected RBCs (and a 39{\%} difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.",
keywords = "Ultrasonics, Acoustic streaming, Surface acoustic waves, Malaria",
author = "Ninnuja Sivanantha and Charles Ma and Collins, {David J.} and Muhsincan Sesen and Jason Brenker and Coppel, {Ross L.} and Adrian Neild and Tuncay Alan",
year = "2015",
doi = "10.1016/j.phpro.2015.08.016",
language = "English",
volume = "70",
pages = "18--20",
editor = "{Declercq de Patin}, {Nico Felicien}",
booktitle = "Physics Procedia",
publisher = "Elsevier",
address = "Netherlands",

}

Sivanantha, N, Ma, C, Collins, DJ, Sesen, M, Brenker, J, Coppel, RL, Neild, A & Alan, T 2015, Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. in NF Declercq de Patin (ed.), Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. vol. 70, Elsevier, Amsterdam, Netherlands, pp. 18-20, International Congress on Ultrasonics, Metz, France, 10/05/15. https://doi.org/10.1016/j.phpro.2015.08.016

Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. / Sivanantha, Ninnuja; Ma, Charles; Collins, David J.; Sesen, Muhsincan; Brenker, Jason; Coppel, Ross L.; Neild, Adrian; Alan, Tuncay.

Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. ed. / Nico Felicien Declercq de Patin. Vol. 70 Amsterdam, Netherlands : Elsevier, 2015. p. 18-20.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

TY - GEN

T1 - Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

AU - Sivanantha, Ninnuja

AU - Ma, Charles

AU - Collins, David J.

AU - Sesen, Muhsincan

AU - Brenker, Jason

AU - Coppel, Ross L.

AU - Neild, Adrian

AU - Alan, Tuncay

PY - 2015

Y1 - 2015

N2 - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.

AB - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.

KW - Ultrasonics

KW - Acoustic streaming

KW - Surface acoustic waves

KW - Malaria

UR - http://www.scopus.com/inward/record.url?scp=84948666092&partnerID=8YFLogxK

U2 - 10.1016/j.phpro.2015.08.016

DO - 10.1016/j.phpro.2015.08.016

M3 - Conference Paper

VL - 70

SP - 18

EP - 20

BT - Physics Procedia

A2 - Declercq de Patin, Nico Felicien

PB - Elsevier

CY - Amsterdam, Netherlands

ER -

Sivanantha N, Ma C, Collins DJ, Sesen M, Brenker J, Coppel RL et al. Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. In Declercq de Patin NF, editor, Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. Vol. 70. Amsterdam, Netherlands: Elsevier. 2015. p. 18-20 https://doi.org/10.1016/j.phpro.2015.08.016