Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

Ninnuja Sivanantha; Charles Ma; David J. Collins; Muhsincan Sesen; Jason Brenker; Ross L. Coppel; Adrian Neild; Tuncay Alan

doi:10.1016/j.phpro.2015.08.016

Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

Ninnuja Sivanantha, Charles Ma, David J. Collins, Muhsincan Sesen, Jason Brenker, Ross L. Coppel, Adrian Neild, Tuncay Alan

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

1 Citation (Scopus)

Abstract

A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.

Original language	English
Title of host publication	Physics Procedia
Subtitle of host publication	Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14
Editors	Nico Felicien Declercq de Patin
Place of Publication	Amsterdam, Netherlands
Publisher	Elsevier
Pages	18-20
Number of pages	3
Volume	70
DOIs	https://doi.org/10.1016/j.phpro.2015.08.016
Publication status	Published - 2015
Event	International Congress on Ultrasonics - Metz, France Duration: 10 May 2015 → 14 May 2015

Conference

Conference	International Congress on Ultrasonics
Country	France
City	Metz
Period	10/05/15 → 14/05/15

Keywords

Ultrasonics
Acoustic streaming
Surface acoustic waves
Malaria

Access to Document

10.1016/j.phpro.2015.08.016

33805198-oaFinal published version, 442 KBLicence: CC BY-NC-ND

Link to Scopus publication

Cite this

Sivanantha, N., Ma, C., Collins, D. J., Sesen, M., Brenker, J., Coppel, R. L., Neild, A., & Alan, T. (2015). Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. In N. F. Declercq de Patin (Ed.), Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14 (Vol. 70, pp. 18-20). Elsevier. https://doi.org/10.1016/j.phpro.2015.08.016

Sivanantha, Ninnuja ; Ma, Charles ; Collins, David J. ; Sesen, Muhsincan ; Brenker, Jason ; Coppel, Ross L. ; Neild, Adrian ; Alan, Tuncay. / Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. editor / Nico Felicien Declercq de Patin. Vol. 70 Amsterdam, Netherlands : Elsevier, 2015. pp. 18-20

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title = "Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells",

abstract = "A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.",

keywords = "Ultrasonics, Acoustic streaming, Surface acoustic waves, Malaria",

author = "Ninnuja Sivanantha and Charles Ma and Collins, {David J.} and Muhsincan Sesen and Jason Brenker and Coppel, {Ross L.} and Adrian Neild and Tuncay Alan",

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Sivanantha, N, Ma, C, Collins, DJ, Sesen, M, Brenker, J , Coppel, RL , Neild, A & Alan, T 2015, Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. in NF Declercq de Patin (ed.), Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. vol. 70, Elsevier, Amsterdam, Netherlands, pp. 18-20, International Congress on Ultrasonics, Metz, France, 10/05/15. https://doi.org/10.1016/j.phpro.2015.08.016

Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. / Sivanantha, Ninnuja; Ma, Charles; Collins, David J.; Sesen, Muhsincan; Brenker, Jason ; Coppel, Ross L.; Neild, Adrian ; Alan, Tuncay.

Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. ed. / Nico Felicien Declercq de Patin. Vol. 70 Amsterdam, Netherlands : Elsevier, 2015. p. 18-20.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AU - Sivanantha, Ninnuja

AU - Ma, Charles

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AU - Sesen, Muhsincan

AU - Brenker, Jason

AU - Coppel, Ross L.

AU - Neild, Adrian

AU - Alan, Tuncay

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AB - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.

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Sivanantha N, Ma C, Collins DJ, Sesen M, Brenker J , Coppel RL et al. Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. In Declercq de Patin NF, editor, Physics Procedia: Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14. Vol. 70. Amsterdam, Netherlands: Elsevier. 2015. p. 18-20 https://doi.org/10.1016/j.phpro.2015.08.016