Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

Ninnuja Sivanantha, Charles Ma, David J. Collins, Muhsincan Sesen, Jason Brenker, Ross L. Coppel, Adrian Neild, Tuncay Alan

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Abstract

A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
Original languageEnglish
Title of host publicationPhysics Procedia
Subtitle of host publicationProceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14
EditorsNico Felicien Declercq de Patin
Place of PublicationAmsterdam, Netherlands
PublisherElsevier
Pages18-20
Number of pages3
Volume70
DOIs
Publication statusPublished - 2015
EventInternational Congress on Ultrasonics - Metz, France
Duration: 10 May 201514 May 2015

Conference

ConferenceInternational Congress on Ultrasonics
CountryFrance
CityMetz
Period10/05/1514/05/15

Keywords

  • Ultrasonics
  • Acoustic streaming
  • Surface acoustic waves
  • Malaria

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