Abstract
A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
Original language | English |
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Title of host publication | Physics Procedia |
Subtitle of host publication | Proceedings of the 2015 International Congress on Ultrasonics, 2015 ICU, Metz, France, May 10-14 |
Editors | Nico Felicien Declercq de Patin |
Place of Publication | Amsterdam, Netherlands |
Publisher | Elsevier |
Pages | 18-20 |
Number of pages | 3 |
Volume | 70 |
DOIs | |
Publication status | Published - 2015 |
Event | International Congress on Ultrasonics - Metz, France Duration: 10 May 2015 → 14 May 2015 |
Conference
Conference | International Congress on Ultrasonics |
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Country | France |
City | Metz |
Period | 10/05/15 → 14/05/15 |
Keywords
- Ultrasonics
- Acoustic streaming
- Surface acoustic waves
- Malaria