Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

Darshita Budhadev, Karinna Saxby, Julia Walton, Gideon Davies, Peter C Tyler, Ralf Schwörer, Martin A Fascione

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks. Rapid access to a hexasaccharide was achieved through iterative solid phase glycosylations on a photolabile resin using Glyconeer™, an automated oligosaccharide synthesiser, followed by photochemical cleavage and glycan purification using simple flash column chromatography.

Original languageEnglish
Pages (from-to)1817-1821
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

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