This paper reports research into adaptation to climate change for regional tourism destinations. It explains the application of a regional tourism adaptation framework model to the Surf Coast destination, within the state of Victoria, Australia. It then examines the usefulness of the framework model in guiding a vulnerability resilience assessment of the destination and developing strategies to increase the destinations resilience, resistance and readiness. A Delphi study was conducted, using a panel of experts, to determine the major risks and opportunities for tourism in the region as well as appropriate adaptation options. Although many of the findings focused on the best way to manage the negative bio-physical impacts of climate change, such as increased bushfire risk or more frequent and intense storms, several opportunities also became apparent including the potential to reduce seasonality. Tourism destination management is already a complex area and the introduction of climate change provides yet another challenge for managers and policy-makers. Consequently, the development and use of a regional adaptation framework can play an important role in assisting destination planning and management.