TY - JOUR
T1 - Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study
AU - Skubisz, Monika Michalina
AU - Dutton, Philip
AU - Duncan, William Colin
AU - Horne, Andrew W
AU - Tong, Stephen
PY - 2013
Y1 - 2013
N2 - The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of >/=15 between days 4-7 of treatment, which has a positive predictive value of 93 for treatment success. Two small studies have proposed a fall in serum hCG between days 0-4 after treatment confers similar, earlier prognostic information, with positive predictive values of 100 and 88 for treatment success. We sought to validate this in a large, independent cohort because of the potentially significant clinical implications. METHODS: We conducted a retrospective study of women (n=206) treated with single-dose methotrexate for ectopic pregnancy (pre-treatment serum hCG levels /=15 fall in serum hCG between days 4-7 of treatment) and an alternate early measure (
AB - The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of >/=15 between days 4-7 of treatment, which has a positive predictive value of 93 for treatment success. Two small studies have proposed a fall in serum hCG between days 0-4 after treatment confers similar, earlier prognostic information, with positive predictive values of 100 and 88 for treatment success. We sought to validate this in a large, independent cohort because of the potentially significant clinical implications. METHODS: We conducted a retrospective study of women (n=206) treated with single-dose methotrexate for ectopic pregnancy (pre-treatment serum hCG levels /=15 fall in serum hCG between days 4-7 of treatment) and an alternate early measure (
UR - http://www.biomedcentral.com/content/pdf/1471-2393-13-30.pdf
U2 - 10.1186/1471-2393-13-30
DO - 10.1186/1471-2393-13-30
M3 - Article
SN - 1471-2393
VL - 13
SP - 1
EP - 5
JO - BMC Pregnancy and Childbirth
JF - BMC Pregnancy and Childbirth
IS - Art. ID: 30
ER -