Using β-amino acids and β-peptide templates to create bioactive ligands and biomaterials

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9 Citations (Scopus)

Abstract

β-Amino acids are being increasingly used in the design of bioactive ligands and more recently in the generation of novel biomaterials. Peptides containing either individual β-amino acid substitutions or peptides comprised entirely of β-amino acids, display unique properties in terms of their structural and/or chemical characteristics. β Peptides form well-defined secondary structures that exhibit different geometries compared to the corresponding α-peptides. β-Peptides, including α-peptides containing only one or two β-amino acids, can be easily modified with different functional groups and are metabolically stable and, together with the predictable side chain topography, have led to the design of a growing number of bioactive β-peptides with a range of biological targets and therapeutic applications. More recently, our understanding of the folding and self-assembly of β-peptides has resulted in the generation of novel biomaterials. The focus of this review is to examine how the structural and chemical properties of β-peptides have been exploited in the design of bioactive peptides and selfassembled nanomaterials.

Original languageEnglish
Pages (from-to)3772-3785
Number of pages14
JournalCurrent Pharmaceutical Design
Volume23
Issue number26
DOIs
Publication statusPublished - 2017

Keywords

  • Bioactive ligand
  • Biomaterials
  • Peptidomimetic
  • Proteolytic stability
  • Self-assembly
  • β-amino acids
  • β-Peptides

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