Use of VacA as a vaccine antigen

Mati Moyat, Dominique Velin

Research output: Contribution to journalReview ArticleOtherpeer-review

2 Citations (Scopus)

Abstract

One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine.

Original languageEnglish
Article number181
Number of pages7
JournalToxins
Volume8
Issue number6
DOIs
Publication statusPublished - 8 Jun 2016
Externally publishedYes

Keywords

  • H. pylori
  • VacA
  • Vaccine

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