Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study

Yen Ying Lim; Kathryn A. Ellis; Karra Harrington; David Ames; Ralph N. Martins; Colin L. Masters; Christopher Rowe; Greg Savage; Cassandra Szoeke; David Darby; Paul Maruff

doi:10.1080/13803395.2011.643227

Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study

Yen Ying Lim, Kathryn A. Ellis, Karra Harrington, David Ames, Ralph N. Martins, Colin L. Masters, Christopher Rowe, Greg Savage, Cassandra Szoeke, David Darby, Paul Maruff

Research output: Contribution to journal › Article › Research › peer-review

138 Citations (Scopus)

Abstract

The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ε4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.

Original language	English
Pages (from-to)	345-358
Number of pages	14
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1080/13803395.2011.643227
Publication status	Published - 1 Apr 2012
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E 4
Australian Imaging, Biomarkers and Lifestyle study
Cognitive testing
CogState

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10.1080/13803395.2011.643227

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Lim, Y. Y., Ellis, K. A., Harrington, K., Ames, D., Martins, R. N., Masters, C. L., Rowe, C., Savage, G., Szoeke, C., Darby, D., & Maruff, P. (2012). Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345-358. https://doi.org/10.1080/13803395.2011.643227

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abstract = "The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ε4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.",

keywords = "Alzheimer's disease, Apolipoprotein E 4, Australian Imaging, Biomarkers and Lifestyle study, Cognitive testing, CogState",

author = "Lim, \{Yen Ying\} and Ellis, \{Kathryn A.\} and Karra Harrington and David Ames and Martins, \{Ralph N.\} and Masters, \{Colin L.\} and Christopher Rowe and Greg Savage and Cassandra Szoeke and David Darby and Paul Maruff",

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Lim, YY, Ellis, KA, Harrington, K, Ames, D, Martins, RN, Masters, CL, Rowe, C, Savage, G, Szoeke, C , Darby, D & Maruff, P 2012, 'Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study', Journal of Clinical and Experimental Neuropsychology, vol. 34, no. 4, pp. 345-358. https://doi.org/10.1080/13803395.2011.643227

Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. / Lim, Yen Ying; Ellis, Kathryn A.; Harrington, Karra et al.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 34, No. 4, 01.04.2012, p. 345-358.

Research output: Contribution to journal › Article › Research › peer-review

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Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study

Abstract

Keywords

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