Use of Testosterone in Postmenopausal Women

Research output: Contribution to journalReview ArticleResearchpeer-review


The role of testosterone in women and its potential as a therapeutic agent continue to attract controversy. The clinical trials of testosterone therapy for women primarily have focused on treatment of female sexual dysfunction, with the largest placebo-controlled studies being of transdermal testosterone in postmenopausal women. Based on the cumulative data from these studies, loss of sexual desire with associated personal distress currently is the only agreed-on indication for judicious testosterone supplementation for postmenopausal women. This article reviews the physiology of testosterone in women, summarizes the findings from observational studies and clinical trials, and considers indications for testosterone use.

Original languageEnglish
Pages (from-to)113-124
Number of pages12
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
Publication statusPublished - Mar 2021


  • Female sexual dysfunction
  • Postmenopausal women
  • Testosterone therapy

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