Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists.

Research output: Contribution to conferencePosterOtherpeer-review

Abstract

Antagonism of the histamine H3 receptor has been shown to be a potential benefit for patients of obesity, allergic rhinitis and cognitive disorders, including schizophrenia and Alzheimer’s. There are two major isoforms of the histamine H3 receptor, hH3-445 and hH3-365, which have been shown to display differential pharmacology. However, no investigation into the kinetic parameters of histamine H3 antagonists, at either isoform, has been performed.
Original languageEnglish
Number of pages1
Publication statusPublished - 2014
EventASCEPT-MPGPCR 2014 - Melbourne Convention and Exhibition Centre, Melbourne, Australia
Duration: 7 Dec 201411 Dec 2014
https://www.asceptasm.com/2014-annual-scientific-meeting/program-keynote-speakers/

Conference

ConferenceASCEPT-MPGPCR 2014
Abbreviated titleASCEPT-MPGPCR
CountryAustralia
CityMelbourne
Period7/12/1411/12/14
Internet address

Cite this

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title = "Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists.",
abstract = "Antagonism of the histamine H3 receptor has been shown to be a potential benefit for patients of obesity, allergic rhinitis and cognitive disorders, including schizophrenia and Alzheimer’s. There are two major isoforms of the histamine H3 receptor, hH3-445 and hH3-365, which have been shown to display differential pharmacology. However, no investigation into the kinetic parameters of histamine H3 antagonists, at either isoform, has been performed.",
author = "Sanja Bosnyak and Darren Riddy and Cook, {Anna Evelyn} and Natalie Diepenhorst and Sexton, {Patrick Michael} and Arthur Christopoulos and Christopher Langmead",
year = "2014",
language = "English",
note = "ASCEPT-MPGPCR 2014, ASCEPT-MPGPCR ; Conference date: 07-12-2014 Through 11-12-2014",
url = "https://www.asceptasm.com/2014-annual-scientific-meeting/program-keynote-speakers/",

}

Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists. / Bosnyak, Sanja; Riddy, Darren; Cook, Anna Evelyn; Diepenhorst, Natalie; Sexton, Patrick Michael; Christopoulos, Arthur; Langmead, Christopher.

2014. Poster session presented at ASCEPT-MPGPCR 2014, Melbourne, Australia.

Research output: Contribution to conferencePosterOtherpeer-review

TY - CONF

T1 - Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists.

AU - Bosnyak, Sanja

AU - Riddy, Darren

AU - Cook, Anna Evelyn

AU - Diepenhorst, Natalie

AU - Sexton, Patrick Michael

AU - Christopoulos, Arthur

AU - Langmead, Christopher

PY - 2014

Y1 - 2014

N2 - Antagonism of the histamine H3 receptor has been shown to be a potential benefit for patients of obesity, allergic rhinitis and cognitive disorders, including schizophrenia and Alzheimer’s. There are two major isoforms of the histamine H3 receptor, hH3-445 and hH3-365, which have been shown to display differential pharmacology. However, no investigation into the kinetic parameters of histamine H3 antagonists, at either isoform, has been performed.

AB - Antagonism of the histamine H3 receptor has been shown to be a potential benefit for patients of obesity, allergic rhinitis and cognitive disorders, including schizophrenia and Alzheimer’s. There are two major isoforms of the histamine H3 receptor, hH3-445 and hH3-365, which have been shown to display differential pharmacology. However, no investigation into the kinetic parameters of histamine H3 antagonists, at either isoform, has been performed.

M3 - Poster

ER -

Bosnyak S, Riddy D, Cook AE, Diepenhorst N, Sexton PM, Christopoulos A et al. Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists.. 2014. Poster session presented at ASCEPT-MPGPCR 2014, Melbourne, Australia.