Use of contemporary prostate brachytherapy approaches in clinical trials

A Haworth, Y Sun, M Ebert, H Reynolds, J Betts, D Wraith, C Mitchell, D Murphy, B Bimal, S Williams

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

Abstract

A number of clinical trials are investigating the role of prostate focal brachytherapy as an alternative treatment to whole gland therapy, offering the opportunity for tumour dose escalation and/or reduced toxicity. Brachytherapy, either low dose rate or high dose rate, offers a treatment choice with both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines for treatment planning approaches along with many other technical issues when practicing focal brachy-therapy. Without consensus guidelines there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centres. We provide a quantitative framework for prostate focal brachytherapy that incorporates a personalized, biological approach that can be used as the foundation for future prostate focal brachytherapy trials.
Original languageEnglish
Title of host publicationMicro-Mini & Nano Dosimetry (MMND) 2018
Subtitle of host publication6–11 February 2018, Mooloolaba, Queensland, Australia
EditorsAnatoly Rozenfeld, Joshija (Josh) Yamada
Place of PublicationBristol UK
PublisherIOP Publishing
Number of pages4
DOIs
Publication statusPublished - 2019
EventMicro-Mini & Nano Dosimetry 2018 - Mooloolaba, Australia
Duration: 6 Feb 201811 Feb 2018
https://mmnditro2018.com/en/

Publication series

NameJournal of Physics: Conference Series
PublisherIOP Publishing
Volume1154
ISSN (Print)1742-6588

Conference

ConferenceMicro-Mini & Nano Dosimetry 2018
Abbreviated titleMMND 2018
CountryAustralia
CityMooloolaba
Period6/02/1811/02/18
Internet address

Cite this

Haworth, A., Sun, Y., Ebert, M., Reynolds, H., Betts, J., Wraith, D., ... Williams, S. (2019). Use of contemporary prostate brachytherapy approaches in clinical trials. In A. Rozenfeld, & J. J. Yamada (Eds.), Micro-Mini & Nano Dosimetry (MMND) 2018: 6–11 February 2018, Mooloolaba, Queensland, Australia (Journal of Physics: Conference Series; Vol. 1154). Bristol UK: IOP Publishing. https://doi.org/10.1088/1742-6596/1154/1/012010
Haworth, A ; Sun, Y ; Ebert, M ; Reynolds, H ; Betts, J ; Wraith, D ; Mitchell, C ; Murphy, D ; Bimal, B ; Williams, S . / Use of contemporary prostate brachytherapy approaches in clinical trials. Micro-Mini & Nano Dosimetry (MMND) 2018: 6–11 February 2018, Mooloolaba, Queensland, Australia. editor / Anatoly Rozenfeld ; Joshija (Josh) Yamada. Bristol UK : IOP Publishing, 2019. (Journal of Physics: Conference Series).
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title = "Use of contemporary prostate brachytherapy approaches in clinical trials",
abstract = "A number of clinical trials are investigating the role of prostate focal brachytherapy as an alternative treatment to whole gland therapy, offering the opportunity for tumour dose escalation and/or reduced toxicity. Brachytherapy, either low dose rate or high dose rate, offers a treatment choice with both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines for treatment planning approaches along with many other technical issues when practicing focal brachy-therapy. Without consensus guidelines there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centres. We provide a quantitative framework for prostate focal brachytherapy that incorporates a personalized, biological approach that can be used as the foundation for future prostate focal brachytherapy trials.",
author = "A Haworth and Y Sun and M Ebert and H Reynolds and J Betts and D Wraith and C Mitchell and D Murphy and B Bimal and S Williams",
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Haworth, A, Sun, Y, Ebert, M, Reynolds, H, Betts, J, Wraith, D, Mitchell, C, Murphy, D, Bimal, B & Williams, S 2019, Use of contemporary prostate brachytherapy approaches in clinical trials. in A Rozenfeld & JJ Yamada (eds), Micro-Mini & Nano Dosimetry (MMND) 2018: 6–11 February 2018, Mooloolaba, Queensland, Australia. Journal of Physics: Conference Series, vol. 1154, IOP Publishing, Bristol UK, Micro-Mini & Nano Dosimetry 2018, Mooloolaba, Australia, 6/02/18. https://doi.org/10.1088/1742-6596/1154/1/012010

Use of contemporary prostate brachytherapy approaches in clinical trials. / Haworth, A; Sun, Y ; Ebert, M; Reynolds, H; Betts, J; Wraith, D; Mitchell, C; Murphy, D ; Bimal, B; Williams, S .

Micro-Mini & Nano Dosimetry (MMND) 2018: 6–11 February 2018, Mooloolaba, Queensland, Australia. ed. / Anatoly Rozenfeld; Joshija (Josh) Yamada. Bristol UK : IOP Publishing, 2019. (Journal of Physics: Conference Series; Vol. 1154).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

TY - GEN

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AU - Haworth, A

AU - Sun, Y

AU - Ebert, M

AU - Reynolds, H

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AU - Wraith, D

AU - Mitchell, C

AU - Murphy, D

AU - Bimal, B

AU - Williams, S

PY - 2019

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N2 - A number of clinical trials are investigating the role of prostate focal brachytherapy as an alternative treatment to whole gland therapy, offering the opportunity for tumour dose escalation and/or reduced toxicity. Brachytherapy, either low dose rate or high dose rate, offers a treatment choice with both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines for treatment planning approaches along with many other technical issues when practicing focal brachy-therapy. Without consensus guidelines there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centres. We provide a quantitative framework for prostate focal brachytherapy that incorporates a personalized, biological approach that can be used as the foundation for future prostate focal brachytherapy trials.

AB - A number of clinical trials are investigating the role of prostate focal brachytherapy as an alternative treatment to whole gland therapy, offering the opportunity for tumour dose escalation and/or reduced toxicity. Brachytherapy, either low dose rate or high dose rate, offers a treatment choice with both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines for treatment planning approaches along with many other technical issues when practicing focal brachy-therapy. Without consensus guidelines there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centres. We provide a quantitative framework for prostate focal brachytherapy that incorporates a personalized, biological approach that can be used as the foundation for future prostate focal brachytherapy trials.

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DO - 10.1088/1742-6596/1154/1/012010

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Haworth A, Sun Y, Ebert M, Reynolds H, Betts J, Wraith D et al. Use of contemporary prostate brachytherapy approaches in clinical trials. In Rozenfeld A, Yamada JJ, editors, Micro-Mini & Nano Dosimetry (MMND) 2018: 6–11 February 2018, Mooloolaba, Queensland, Australia. Bristol UK: IOP Publishing. 2019. (Journal of Physics: Conference Series). https://doi.org/10.1088/1742-6596/1154/1/012010