Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major

Phillip Wong, Frances Milat, Peter J. Fuller, Peter G. Kerr, James C. G. Doery, Danielle H. Oh, Dana Jackson, Matthew T. Gillespie, Donald K. Bowden, Sant-Rayn Pasricha, Kenneth K. Lau

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Abstract

Asymptomatic urolithiasis is common and of mixed composition in patients with β-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores.
Original languageEnglish
Pages (from-to)1064-1067
Number of pages4
JournalInternal Medicine Journal
Volume47
Issue number9
DOIs
Publication statusPublished - Sep 2017

Keywords

  • computed tomography
  • kidney stone
  • osteoporosis
  • thalassaemia
  • urolithiasis

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