Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment

Reetu Singh, Katherine Denton, John Bertram, John Dowling, Karen Moritz

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Fetal uninephrectomy (uni-x) in male sheep at 100 days of gestation (term=150days) reduces overall nephron endowment without affecting birth weight. Offspring have a lower glomerular filtration rate (GFR) and elevated mean arterial pressure (MAP) at 6 months of age. This study investigated whether this reduction in renal function was associated with impaired urine concentrating ability at 6 months of age and exacerbated with ageing (4 years) and examined response to 1) non-pressor dose of exogenous arginine vasopressin (AVP (0.2 microg/kg/h i.v.) and 2) 30 hours of water deprivation. Basal MAP was higher in uni-x animals at both ages, and became further elevated with age compared to the sham group (elevation in MAP with age; sham: 4mmHg, uni-x: 9 mmHg, P(group x age)
Original languageEnglish
Pages (from-to)F1168 - F1176
Number of pages9
JournalAmerican Journal of Physiology-Renal Physiology
Volume301
Issue number6
DOIs
Publication statusPublished - 2011

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