Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery

Christian Albert, Annemarie Albert, Rinaldo Bellomo, Siegfried Kropf, Prasad Devarajan, Sabine Westphal, Hassina Baraki, Ingo Kutschka, Christian Butter, Michael Haase, Anja Haase-Fielitz

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Aim: To assess weather doctors' clinical risk-assessment for major adverse kidney events (MAKE) and acute kidney injury (AKI) after open-heart surgery would improve when being informed about neutrophil gelatinase-associated lipocalin (NGAL) test result at ICU admission. Patients & Methods: Clinical risk-assessment for MAKE and AKI were performed with and without providing NGAL test result and compared in an exploratory- and a validation-cohort using reclassification metrics, exemplary category-free net reclassification improvement (cfNRI). Results: Exploratory cohort: doctors' prediction of MAKE (cfNRI = 0.750 [0.130-1.370]; p = 0.018) and AKI (cfNRI = 0.565 [0.001-1.129]; p = 0.049) improved being provided with NGAL test information. This finding was confirmed in the validation-cohort (MAKE cfNRI = 0.930 [0.188-1.672]; p = 0.014) and the combined-cohort (MAKE: cfNRI = 0.847 [0.371-1.323], p < 0.001); AKI: cfNRI = 0.468 [0.099-0.836; p = 0.013]). Improvements mostly generated from correctly reclassifying patients who not developed events (p < 0.001). Conclusion: Biomarker informed risk-assessment is superior in predicting MAKE and AKI after open-heart surgery.

Original languageEnglish
Pages (from-to)975-985
Number of pages11
JournalBiomarkers in Medicine
Issue number9
Publication statusPublished - Sep 2018
Externally publishedYes


  • acute kidney injury (AKI)
  • cardiac surgery
  • major adverse kidney events (MAKE)
  • neutrophil gelatinase-associated lipocalin (NGAL)
  • risk prediction

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